The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...

A critical step in establishing a successful nitrogen-fixing symbiosis between rhizobia and legume plants is the entrapment of the bacteria between root hair cell walls, usually in characteristic 180 degrees to 360 degrees curls, shepherd's crooks, which are formed by the host's root hairs. Purified bacterial signal molecules, the nodulation factors (NFs), which are lipochitooligosaccharides, i...

[1] The transport of black carbon (BC) to polar regions is studied using the University of Michigan IMPACT aerosol model driven by two sets of meteorological fields from the NCAR CAM5 and GFDL AM3 models. The sensitivity of the transport of BC to wet deposition processes is tested by varying the wet deposition in large-scale precipitation. BC concentrations and deposition in polar regions are s...

For a polynomial p(z) of degree n, having all zeros in |z|< k, k< 1, Dewan et al [K. K. Dewan, N. Singh and A. Mir, Extension of some polynomial inequalities to the polar derivative, J. Math. Anal. Appl. 352 (2009) 807-815] obtained inequality between the polar derivative of p(z) and maximum modulus of p(z). In this paper we improve and extend the above inequality. Our result generalizes certai...

Root hair polar growth is endogenously controlled by auxin and sustained by oscillating levels of reactive oxygen species (ROS). These cells extend several hundred-fold their original size toward signals important for plant survival. Although their final cell size is of fundamental importance, the molecular mechanisms that control it remain largely unknown. Here we show that ROS production is c...

A fragment of DNA was cloned which complemented a polar flagellum-defective (pof) mutation of Vibrio alginolyticus. The fragment contained two complete and two partial open reading frames (ORFs) (ORF2 and -3 and ORF1 and -4, respectively). The presumed product of ORF2 has an amino acid sequence with a high degree of similarity to that of RpoN, which is an alternative sigma factor (sigma54) for ...

Formation of a division septum near a randomly chosen pole during sporulation in Bacillus subtilis creates unequal sized daughter cells with dissimilar programs of gene expression. An unanswered question is how polar septation activates a transcription factor (σ(F)) selectively in the small cell. We present evidence that the upstream regulator of σ(F), the phosphatase SpoIIE, is compartmentaliz...

This paper addresses the polar profile of ancient proteins using a comparative study of amino acids found in 25 000 000-year-old shells described in Abelson's work. We simulated the polar profile with a computer platform that represented an evolutionary computational toy model that mimicked the generation of small proteins starting from a pool of monomeric amino acids and that included several ...

Wireless broadband digital communication systems are facing more and more critical power efficiency problems. Crest Factor (PAPR) is reported to be in 10-12dB range for WiMAX 802.16e systems implementing OFDM IFFT-1024 and 64-QAM modulation. In this work, outphasing (LINC) and Polar transmitter architectures are investigated and compared with Direct Conversion architecture. Complete system solu...

Vertebrate oocyte maturation is an extreme form of asymmetric cell division, producing a mature egg alongside a diminutive polar body. Critical to this process is the attachment of one spindle pole to the oocyte cortex prior to anaphase. We report here that asymmetric spindle pole attachment and anaphase initiation are required for localized cortical activation of Cdc42, which in turn defines t...