OBJECTIVE Dynamic loads lead to increases in bone mass. How long these gains are maintained after cessation of loading, however, is not fully understood. METHODS A long term study was performed in which skeletal changes were monitored by pQCT every 2-4 weeks (wks) for a 12 wk period after application of external loading using four-point bending device on 10 wk old female C57BL/6J mice. RESU...

Hybrid staggered architecture composites, like nacre and bone, are known for two discernible aspects: superior strength and synergistic toughness. What is lacking is the scientific rationale proving suitability of these materials under impact/time dependent loading. The current investigation aims to address the structure-property correlationship of these materials by development of an analytica...

Penetration measurements through commercially available filtering facepieces were performed with monodisperse DEHS aerosols ranging from 0.03 μm to 0.40 μm (either singly charged or neutralized), before and after 500 mg of paraffin oil loading. The distinct behavior of Coulomb and polarization capture efficiency is studied: as in the case of non loading also in the case of loading 500 mg of par...

OBJECTIVE To investigate the acute effects of isolated eccentric and concentric calf muscle exercise on Achilles tendon sagittal thickness. DESIGN Within-subject, counterbalanced, mixed design. SETTING Institutional. PARTICIPANTS 11 healthy, recreationally active male adults. INTERVENTIONS Participants performed an exercise protocol, which involved isolated eccentric loading of the Achi...

It is well established that certain structural buckling problems are extremely sensitive to small changes in configuration: geometric imperfections, load application, symmetry, boundary conditions, etc. This paper considers the behavior of a very shallow arch under lateral point loading, and specifically under the influence of changes in the thermal environment. In some ways the system under st...

To ensure optimal skeletal development, mechanical loading is imperative. The consequences of the removal of, or complete absence of, mechanical loading are illustrated by the clinical condition of cerebral palsy (CP). Clinical and radiological evaluation of children with CP provides an insight into how the growing skeleton develops when mechanical loading is reduced due to non-physiological mu...

BACKGROUND Aggressive platelet inhibition is crucial to reduce myocardial injury and early cardiac events after coronary intervention. Although observational data have suggested that pretreatment with a high loading dose of clopidogrel may be more effective than a conventional dose, this hypothesis has never been tested in a randomized trial. METHODS AND RESULTS A total of 255 patients schedu...

BACKGROUND No data exist about the impact of high residual platelet reactivity (HRPR) after clopidogrel loading on long-term clinical outcome in patients undergoing drug-eluting stent (DES) implantation for unprotected left main disease (ULMD). METHODS AND RESULTS Consecutive patients who underwent percutaneous coronary intervention for ULMD had prospective platelet reactivity assessment by l...

Purpose: The aim of this study was to clinically evaluate immediate functionally loaded (IFL) and immediate nonfunctionally loaded (INFL) implants for various indications compared to a control group with a conventional healing period. Materials and Methods: Two hundred fifty-three patients took part in the study. A total of 702 XiVE implants (Dentsply/Friadent, Mannheim, Germany) were placed: 2...

Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the efficiency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages the proposed method over ...