A rhodium-catalyzed methodology leads to four kinds of novel podophyllotoxin derivatives starting from readily available in a late-stage functionalization strategy. Some them are found show excellent anticancer activity. This direct C−H can be expressed the (roots podophyllum species) being converted into (leaves) by rhodium catalysis. More information Research Article C. Li, H. Liu and co-work...

linum album l. is containing pharmaceutical composition podophyllotoxin(ptox) which is currently being used as a precursor to semi-synthetic anticancer drugs etoposide, teniposide and etopophos. cell culture is as an important source for the production of ptox. several strategies, including treatment with elicitors have shown for enhanced production of secondary metabolites in cell culture syst...

For the first time callus and suspension cultures of Linum mucronatum ssp. annenum were initiated, grown in darkness at 25 degrees C and analyzed for lignans. 6-Methoxypodophyllotoxin was the main lignan besides smaller amounts of podophyllotoxin isolated and identified by chromatographic methods as well as by 1H NMR.

Purified calf brain tubulin has been induced to self-aggregate in vitro into paracrystalline structures by the anti-cancer drug vinblastine. The size, shape, optical birefringence, and drug stoichiometry of these tubulin-vinblastine paracrystals are similar to those of paracrystals formed in vivo. Similar structures can be formed with vincristine and desacetylvinblastine, but not with colchicin...

Elicitors could be used as the enhancer of plant secondary-metabolite synthesis and could play an important role in biosynthetic pathways of important medicinal compounds. The present study investigated the effect of abiotic elicitor (fungal extract of Fusarium graminearum) and two abiotic elicitors (methyl jasmonate and salicylic acid) at different concentrations in 18- and 30-day-old cultures...