نتایج جستجو برای: pluripotent stem cells

تعداد نتایج: 1506620  

2012
Chih-Chien Tsai Shih-Chieh Hung

Pluripotency, the capacity of a cell to give rise to differentiated derivatives that represent each of the three primary germ layers, belongs to the cells that are located within the inner cell mass (ICM) of the developing blastocyst. Functional studies have identified a group of transcription factors, the pluripotency transcription factors that affect the pluripotent capacity. Within this grou...

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Journal: :Theriogenology 2012
Z Tancos C Nemes Z Polgar E Gocza N Daniel T A E Stout P Maraghechi M K Pirity P Osteil Y Tapponnier S Markossian M Godet M Afanassieff Z Bosze V Duranthon P Savatier A Dinnyes

Pluripotent stem cells have the capacity to divide indefinitely and to differentiate into all somatic cells and tissue lines. They can be genetically manipulated in vitro by knocking genes in or out, and therefore serve as an excellent tool for gene function studies and for the generation of models for some human diseases. Since 1981, when the first mouse embryonic stem cell (ESC) line was gene...

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Journal: International Journal of Fertility and Sterility 2012
Choobineh K, Ghorbanian MT Paylakhi SH Salehnia M Zavareh S

Background: It is assumed that adult stem/progenitor cells are responsible for cycling remodeling of the uterus endometrium throughout the reproductive life of the female. This study aimed to identify and localize stem/progenitor cells in the mice uterus using immunohistochemistry. Materials and Methods: 6-8 weeks old virgin female NMRI mice were submitted to the vaginal smear examination to de...

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ژورنال: Anatomical Sciences Journal 2010
Moslem, Mohsen, Baharvand, Hossein, Rezazadeh Valoujerdi, Mojtaba,

Purpose: Isolating human induced pluripotent stem cells (hiPS)-derived mesenchymal progenitors as a new source of mesenchymal cells which can differentiate into different lineages like adipose and bone. Materials and Methods: After 7 days of hiPS1 culture on matrigle coated dishes, spindle like cells around colonies were removed by cell scraper. These cells that had mesenchymal like morphology ...

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Journal: International Journal of Fertility and Sterility 2010
Viville S

The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...

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Journal: :Acta biochimica Polonica 2015
Józef Dulak Krzysztof Szade Agata Szade Witold Nowak Alicja Józkowicz

Stem cells are self-renewing cells that can differentiate into specialized cell type(s). Pluripotent stem cells, i.e. embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) differentiate into cells of all three embryonic lineages. Multipotent stem cells, like hematopoietic stem cells (HSC), can develop into multiple specialized cells in a specific tissue. Unipotent cells differenti...

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Journal: :international journal of reproductive biomedicine 0
ali a movassagh-pour mojdeh salehnia ali a pourfatollah sayed m moazzeni

background: embryonic stem cells (esc) are pluripotent cells which have been used as a model to study the mechanism that control the embryogenesis and early mammalian development in vitro. the aim of this study was to isolate and produce embryonic stem cells from late blastocyst stage embryos in mice. materials and methods: blastocyst stage embryos from pregnant nmri mice were obtained and cult...

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2017
Tomoko Yamashita Yuki Miyamoto Yoshio Bando Takashi Ono Sakurako Kobayashi Ayano Doi Toshihiro Araki Yosuke Kato Takayuki Shirakawa Yutaka Suzuki Junji Yamauchi Shigetaka Yoshida Naoya Sato

Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of disease remain poorly understood. Primate pluripotent stem cell-derived oligodendrocytes are expected to help elucidate the molecular pathogenesis of...

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Journal: :Physiological reviews 2016
Elena Matsa John H Ahrens Joseph C Wu

Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human disease modeling, with an enormous potential to serve as paradigm shifting platforms for preclinical trials, personalized clinical diagnosis, and drug treatment. In this review, we describe how hiPSCs could transition cardiac healthcare away from simple disease diagnosis to prediction and prevention, bridging t...

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Journal: :Haematologica 2014
Guanheng Yang Wansheng Shi Xingyin Hu Jingzhi Zhang Zhijuan Gong Xinbing Guo Zhaorui Ren Fanyi Zeng

Although β-thalassemia is one of the most common human genetic diseases, there is still no effective treatment other than bone marrow transplantation. Induced pluripotent stem cells have been considered good candidates for the future repair or replacement of malfunctioning organs. As a basis for developing transgenic induced pluripotent stem cell therapies for thalassemia, β(654) induced plurip...

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