Many transition metal complexes have unique physicochemical properties that can be efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double-stranded DNA has been assumed to be the main binding target; however, recent studies have shown that nucleosomal DNA as well as proteins can act as dominant molecular binding partners. This has raised new questions about the ...

The five platinum anticancer compounds currently in clinical use conform to structure-activity relationships formulated (M. J. Cleare and J. D. Hoeschele, Bioinorg. Chem., 1973, 2, 187-210) shortly after the discovery that cis-diamminedichloroplatinum(II), cisplatin, has antitumor activity in mice. These compounds are neutral platinum(II) species with two am(m)ine ligands or one bidentate chela...

Dioxin-like compounds including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) are polyhalogenated aromatic hydrocarbons (PHAHs) that bio-concentrate, bio-accumulate and bio-magnify because of their hydrophobicity, and persistence in the environment. These compounds are formed as a result of incomplete combustion during cert...

A series of mono- and dinuclear alkynylplatinum(II) terpyridine complexes containing the hydrophilic oligo(para-phenylene ethynylene) with two 3,6,9-trioxadec-1-yloxy chains was designed and synthesized. The mononuclear alkynylplatinum(II) terpyridine complex was found to display a very strong tendency toward the formation of supramolecular structures. Interestingly, additional end-capping with...

metal—polyaniline nanocomposites such as platinum-polyaniline nanocomposite is prepared by insitu oxidative polymerization of aniline and reduction of pt+4 ions into pt nanoparticles. thepolymerization of aniline was carried out in the presence of 1(2ptcn6 [potassium hexa cyanoplatinate (iv)] as oxidizing agent. during the reaction aniline monomers undergo oxidation andform polyaniline (pant) w...

Triplet emitters based on platinum(II) complexes have gained major attention in recent times. They can form aggregates or excimers, causing shifts in the emitted wavelengths and affecting the photoluminescence quantum yields (PLQYs). Even though this effect can be exploited for the construction of white organic light emitting diodes (WOLEDs), it is disadvantageous for applications where color p...

DNA-alkylating agents that are platinum complexes induce apoptotic responses and have wide application in cancer therapy. The potential for platinum compounds to modulate signal transduction events that contribute to their therapeutic outcome has not been extensively examined. Among the signal transducer and activator of transcription (STAT) proteins, Stat3 activity is frequently up-regulated i...

The cathodic dissolution of platinum, resulting from the oxygen reduction reaction (ORR) or hydrogen peroxide reduction on platinum, has been investigated. Highly oxidizing hydroxyl radicals (OH•) are believed to be the species responsible for the platinum dissolution phenomenon. These radicals are produced from the ORR byproduct, hydrogen peroxide, through a 1 electron reduction pathway (H2O2 ...

Absrract This paper describes research in tw'o areas: heterogeneous catalysis and molecular self-asiembly. The work in heterogeneous catalysis used the platinum-catalyzed hydrogenation of diolefin(dialkyl)platinum(ll) complexes to generate platinum surface alkyls of known structure. The structure and rcactrvity of these surface alkyls were inferred from characteristic processes occurring on the...