نتایج جستجو برای: platinum iv complexes
تعداد نتایج: 330620 فیلتر نتایج به سال:
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger apoptosis in various cancer cell types. However, many cancer cells are resistant to death receptor-mediated apoptosis. Combination therapy with platinum complexes may affect TRAIL-induced signaling via modulation of various steps in apoptotic pathways. Here, we show that cisplatin or a more potent platinum(I...
Platinum(II) complexes with rigid and electron donating ligands are efficient phosphorescent emitters at room temperature. However, the excited-state lifetimes of these are, in general, relatively long. This problem, which can result degradation emitter, be overcome by exploiting natural tendency platinum to form metallophilic interactions aggregates. Herein, we report platinum(II) bimetallic 1...
Coordinatively and electronically unsaturated species are shortlived intermediates in a large number of reactions involving late transition metal complexes.1 These species containing an “opensite” in the metal coordination sphere are notoriously difficult to characterize, owing to their inherent reactivity.2 In particular, fivecoordinate Pt(IV) alkyl species have been consistently proposed as k...
Various Pt(IV) diazides have been investigated over the years as light-activatable prodrugs that interfere with cell proliferation, accumulate in cancer cells and cause cell death. The potencies of the complexes vary depending on the substituted amines (pyridine=piperidine>ammine) as well as the coordination geometry (trans diazide>cis). Light-activated Pt(IV) diazides tend to be less specific ...
Although some of the platinum(II/IV) and rhodium(III) chemistry is considered ‘old’ and wellknown, the application of modern multinuclear NMR spectroscopic methods to this chemistry in solution reveals new details about their rich and relevant solution chemistry. In this paper we will briefly illustrate that the highly-sensitive 195 Pt NMR shielding is an excellent probe to explore aspects such...
A quantitative structure–property relationship (QSPR) study was performed for predicting the hydrophobicity of Pt(IV) complexes. Two four-parameter equations, one based solely on structural descriptors derived from electrostatic potentials (ESPs) molecular surface, and other integrated ESP with surface area (AS), were firstly constructed. Mechanistic interpretations introduced elucidated in ter...
two newly-created water-soluble complexes of palladium(ii)/platinum(ii)-dithiocarbamate, [pd/pt(phen)(pyr-dtc)]no3 (phen = 1,10-phenanthroline and pyr-dtc = pyrrolidinedithiocarbamate) were synthesized. also, their chemical characteristics are reported in the current research paper. in these complexes, the dithiocarbamato ligand coordinates to pt(ii) or pd(ii) center with two sulfur atoms as bi...
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