Imaging mass cytometry was used for direct visualization of platinum localization in tissue sections from tumor and normal tissues of cisplatin-treated mice bearing pancreas cancer patient-derived xenografts. This recently-developed technology enabled simultaneous detection of multiple markers to define cell lineage, DNA damage response, cell proliferation and functional state, providing a high...

Self-assembled monolayers and bulk films of thioanilines, polymerized on gold and platinum surfaces, have been characterized and compared to bulk polyaniline (PANI) films. In a previous study [Kuwabata; et al. Langmuir 1999, 15, 6807-6812], only one redox couple was observed in the cyclic voltammetric profile of a polymerized monolayer of thioaniline on gold, in contrast to the known profiles o...

C a r b o n f u n c t i o n a l s i l a n e s b e a r i n g c o u m a r i n t y p e f u n c t i o n a l g r o u p s a r e o f i n t e r e s t d u e t o t h e i r p o t e n t i a l i m p o r t a n c e as p r e c u r s o r s i n c o s m e t i c i n d u s t r i e s . W e r e p o r t t h e s y n t h e s i s o f s o m e 4 o r g a n o s i l i c o n d e r i v a t i v e s o f 7 h y d r o x y c o u m a ...

In an effort to expand the therapeutic range of platinum anticancer agents, several new approaches to platinum-based therapy, including nanodelivery, are under active investigation. To better understand the effect of ligand lipophilicity on the encapsulation of Pt(IV) prodrugs within polymer nanoparticles, the series of compounds cis,cis,trans-[Pt(NH3)2Cl2L2] was prepared, where L = acetate, pr...

A series of platinum(II) complexes bearing Delta (4)-1,2,4-oxadiazoline ligands have been synthesized and characterized. Their in vitro antitumor activity has been assessed in platinum-sensitive and -resistant human ovarian cancer cell lines (PEO1, PEOCisR, PEOCarboR, and SK-OV3), as well as in colon cancer (SW948) and testicular cancer cell lines (N-TERA). All compounds tested showed potent cy...

Based on the analytic derivatives formalism for the spin-free normalized elimination of the small component method, a new computational scheme for the calculation of the electric field gradient at the atomic nuclei was developed and presented. The new computational scheme was tested by the calculation of the electric field gradient at the mercury nucleus in a series of Hg-containing inorganic a...

Photo-induced reversible sorption of azo dyes on titania xerogels is observed, which is based on the photo-switchable change of the acetylacetonato anchors in the xerogels. The photoisomerization of azo compounds that regulates many gate-keeper-like host-guest interaction systems is excluded as the determinant.

Platinum drugs remain the backbone of many antineoplastic regimens. Among the numerous chemical or pharmacological effects of platinum drugs, some aspects tend to be under-reported. Thus, this perspective paper intends to stress some neglected properties of platinum drugs: first, the physico-chemical characteristics (aquation reaction kinetics) that determine site-specific toxicity; second, the...

Ethidium monoazide and propidium monoazide (EMA and PMA) have been used in combination with PCR for more than a decade to facilitate the discrimination of live and dead bacteria (LD discrimination). These methods, however, require many laborious procedures, including the use of a darkroom. Here, we demonstrate an innovative use of palladium compounds involving lower limits of detection and quan...

Interest in platinum-chain complexes arose from their unusual oxidation states and physical properties. Despite their compositional diversity, isolation of crystalline chains has remained challenging. Here we report a simple crystallization technique that yields a series of dimer-based 1D platinum chains. The colour of the Pt(2+) compounds can be switched between yellow, orange and blue. Sponta...