نتایج جستجو برای: platelet storage lesions
تعداد نتایج: 460766 فیلتر نتایج به سال:
OBJECTIVE The platelet storage lesion accelerates platelet clearance after transfusion, but the underlying molecular mechanism remains elusive. Although inhibiting sheddase activity hampers clearance of platelets with storage lesion, the target platelet protein responsible for ectodomain shedding-induced clearance is not definitively identified. Monoclonal antibody 5G6 was developed recently to...
Platelet concentrates can be stored for five days at 22 C. Our objective was to increase the storage of platelets to 7 days by decreasing the storage temperature. Lower temperature may minimize chances of bacterial proliferation and also maintain platelet functions to optimum level. The study sample iincluded 25 blood donors of both sex in State Blood Bank, Chhatrapati Shahuji Maharaj Medical U...
A quantitative study of various aspects of platelet function was carried out in eight patients with typical hairy-cell leukaemia (HCL). In at least two patients platelet aggregation was convincingly reduced to more than one aggregating agent (ADP, adrenaline, collagen, thrombin, and ristocetin). Granular storage capacity for {(14)C} 5-HT was reduced in five of the six patients tested. The two p...
IntroductionThe treatment of degenerative meniscal lesions usually consists conservative measures such as physical therapy or knee injections. Recently, the use orthobiologics, in form platelet-rich plasma and cell-based therapies, gained huge popularity orthopedic practice.ObjectivesThe aim present systematic review is to summarize available evidence concerning orthobiologics lesions.Data sour...
Platelet concentrates were prepared at twice the normal concentration and stored at room temperature for 7 days in either standard bags (controls) or bags to which 1 or 2 g of Amberlite resin beads charged with dibasic phosphate had been added. The resin beads served as a buffer system by providing a "slow release" form of phosphate ions as well as by binding CO2 produced during platelet metabo...
Platelet concentrates were prepared for in vitro storage in either Fenwal PL-732 or Cutter CLX platelet packs. The units were stored at 22 degrees C for seven days with either horizontal or tumbler agitation. Measurement of pH, hypotonic shock response and serotonin uptake indicated in vitro viability was well maintained during 5-7 days storage using either type of pack with either mode of agit...
BACKGROUND Intravascular red cell hemolysis impairs nitric oxide (NO)-redox homeostasis, producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell storage under standard conditions results in reduced integrity of the erythrocyte membrane, with formation of exocytic microvesicles or microparticles and hemolysis, which we hypothesized could impair vascular function ...
Citrated platelet-rich plasma (PAP) was kept at cold temperatures or room temperature. After 4 hr or more at these temperatures, the PRPs were warmed 1 hr at 37#{176}C. This prevents the spontaneous aggregation seen in chilled PRP that is stirred immediately after warming. Platelet aggregation in response to connective tissue (CT), epinephrine, and adenosine diphosphate (ADP) was considerably g...
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