malaria is a major international public health problem. drug-resistant parasites have made treatment and control of malaria more difficult. therefore, safe, affordable and effective new drugs are urgently needed. traditional medicine is an important source for new drugs. determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms lik...

background: plasmodium vivax is responsible for approximately 80 million malaria cases in the world. apical membrane antigen1 (ama-1) is a type i integral membrane protein present in all plasmo­dium species. ama-1 interferes in critical steps of invasion of human hepatocytes by sporo­zoites and red blood cells by merozoites and is one of the most immunodominant antigens for elicit­ing a protect...

b ackground: animal models with various combination of host-parasite have long been employed to study malaria pathogenesis. here, we describe the combination of plasmodium berghei anka infec- tion in inbred icr mice as a model of cerebral malaria (cm). m ethods: infection in mice was initiated by intraperitoneal injection of 2 x 107  (0.2ml) parasitized red blood cells (prbcs). r esults: this m...

abstract background malaria is an acute and chronic illness characterized by paroxysms of fever, chills, sweating, fatigue, anemia, and splenomegaly. most malarial deaths occur in infants and young children.anemia in malaria has diverse pathophysiologic mechanisms such as direct invasion of red cells, in the following, we presented comparison of hematological aspects: children with malaria and ...

Malaria is transmitted to humans by mosquitoes of the genus Anopheles. Malaria is known to be caused by four plasmodia species, namely Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, with P. falciparum being the most lethal. There are increasing reports of a fifth human-infecting species, Plasmodium knowlesi, which has been described in south-east Asian countr...

Malaria is an infectious disease caused by the genus Plasmodium such as Plasmodium falciparum (P. falciparum), Plasmodium ovale, Plasmodium vivax and Plasmodium malariae. Among them, P. falciparum is the parasite responsible for most severe diseases and fatal cases, which may kill over one millions of people per annum. The parasite, P. falciparum is genetically diverse and has multiple independ...

Malaria still poses a threat to the health of residents and travellers in tropical countries, which causes high morbidity and mortality. The present study was undertaken for cultivation of the Plasmodium vivax in McCoy’s 5A medium and observed for their growth. Cultivation of Plasmodium vivax was done according to modified method of Jensen and Trager (1980) in immature red blood cells (reticulo...

The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte invasion. Here we described a member of the gene family found in P. falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears no...

The genome sequence of the human malaria parasite, Plasmodium falciparum, was released almost a decade ago. A majority of the Plasmodium genome, however, remains annotated to code for hypothetical proteins with unknown functions. The introduction of forward genetics has provided novel means to gain a better understanding of gene functions and their associated phenotypes in Plasmodium. Even with...

The human malarial parasite Plasmodium falciparum is one of the world's most devastating pathogen. Its capability to regulate its genes under various stages of its life cycle as well as under unfavourable environmental conditions has led to the development of vaccine resistant strains. Similarly, under drug pressure it develops mutations in the target genes. These mutations confer mid and high-...