Plasmacytoma are extramedullary accumulations of plasma cells. Most extramedullary Plasmacytomas are associated with the upper respiratory tract. The mediastinum is rarely involved. We report a rare case of mediastinal plasmacytoma with multiple myeloma. The patient is 66 year old woman presented with bone pains and mediastinal mass on CT scan and MRI. The preliminary diagnosis of occult lung c...

INTRODUCTION Extramedullary plasmacytoma is a rare plasma cell neoplasm. Plasmacytomas are most commonly found in the head and neck region, but can occur in many other locations. They rarely occur in the testis, and are commonly associated with concurrent multiple myeloma at the time of diagnosis. Isolated plasmacytoma of the testis is exceedingly rare, with few cases reported in the literature...

The prognosis of solitary plasmacytoma varies greatly, with some patients recovering after surgical removal or local fractional radiation therapy, and others progressing to multiple myeloma years later. Primary detection of progression to multiple myeloma is important in the treatment of solitary plasmacytoma. There have been several analyses of the risk factors involved in the early progressio...

2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immun...

BACKGROUND Previous reports suggest an as yet unidentifiable subset of patients with plasmacytoma will progress to myeloma. The current study sought to establish the risk of developing myeloma and determine the prognostic factors affecting the progression of disease. METHODS Patients with plasmacytoma diagnosed between 1973 and 2005 were identified in the SEER database(1164 patients). Patient...

Introduction: Plasmacytoma is a localized collection of malignant plasma cells. The disease can be divided into solitary plasmacytoma of the bone (SPB) and extramedullary plasmacytoma (EMP), both of which are distinct entities. An EMP, the rarer of the two, has soft tissue infiltration by clonal plasma cells without any occult or systemic myeloma. Whereas, SPB has a solitary lytic bone lesion w...

Multiple myeloma (MM) and plasmacytomas are cancers of antibody-secreting cells (ASCs). PRDM1/BLIMP1 is an essential regulator of ASC development. Histologic evidence shows that 100% of MM expresses PRDM1/BLIMP1, indicating that PRDM1/BLIMP1 is important for the development or persistence of MM. In contrast, some diffuse large B-cell lymphomas (DLBCLs) lose PRDM1 expression, suggesting that PRD...

Extramedullary plasmacytoma is a rare and unusual complication of multiple myeloma (MM). Some sites for the extramedullary involvement MM are liver, spleen, lymph node, lung, skin. Renal failure another due to kidney, uric acid nephropathy, hemoconcentration, or light chain disease. This study reported case with presentation. She was 61-year-old woman who admitted internal ward severe renal fai...

Plasmacytoma refers to a distinct and localized growth of plasma cells that are neoplastic monoclonal in nature. Solitary plasmacytomas (SP) can be categorized into two groups based on their location: solitary bone plasmacytoma (SBP), which most commonly occurs the vertebrae secondarily long bones, extramedullary (EMP), encompassing SPs found outside bone. Long bones frequently affected plasmac...