UNLABELLED Placental site nodules (PSNs) and epithelioid trophoblastic tumors (ETTs) respectively represent non-neoplastic and neoplastic lesions of chorionic-type intermediate trophoblasts (ITs). Many patients with a PSN have a history of a cesarean section (CS) or therapeutic abortion. Recent evidence shows that a PSN may progress to an ETT. Herein, we describe a coexisting ETT and placental ...

This study is aimed at answering whether aging/health-related web sites of different domain extensions (i.e. .com, .edu, .gov and .org) differ in their accessibility and usability, and whether these two measures are correlated. The usability and accessibility of governmental, organizational, educational and commercial aging/health-related web sites were compared using two automatic evaluation t...

Trophoblastic neoplasms are a truly fascinating set of diseases that arise from a failed gestation. A molar pregnancy is an allograft of fetal tissue typically containing only paternal chromosomes that may invade the maternal decidua following a failed gestation that may have arisen up to decades earlier. Choriocarcinoma (CCA), the most common malignant form of trophoblastic disease, represente...

This study is aimed at answering whether aging/health-related web sites of different domain extensions (i.e. .com, .edu, .gov and .org) differ in their accessibility and usability, and whether these two measures are correlated. The usability and accessibility of governmental, organizational, educational and commercial aging/health-related web sites were compared using two automatic evaluation t...

Placental site trophoblastic tumor is a very rare variant of gestational trophoblastic disease which differs histologically and immunocytochemically from gestational choriocarcinoma. The English language literature includes only 74 reported cases. Seventeen patients have been managed at Charing Cross Hospital with this diagnosis. The median follow-up is 4.6 years, and the 5-year overall surviva...

Objective: This study was aimed at analyzing the clinicopathological features and treatment of patients with placental site trophoblastic tumor (PSTT) in Shanghai, China, and to investigate high-risk factors for metastasis and relapse. Methods: Thirteen patients with placental site trophoblastic tumors who received treatment in the Obstetrics and Gynecology Hospital Affiliated with Fudan Univer...

Gestational trophoblastic disease (GTD) represents a spectrum of lesions characterised by an abnormal proliferation of trophoblast, including complete hydatidiform mole, partial hydatidiform mole, invasive hydatidiform mole, choriocarcinoma, placental site trophoblastic tumour, epithelioid trophoblastic tumour, placental site nodule and plaque, and exaggerated placental site reaction. Complete ...

Introduction: Gestational trophoblastic disease (GTD) includes hydatiform mole, choriocarcinoma, placental site tumor, and epithelial tumor. Also, molar pregnancy can happen as an ectopic pregnancy. The coincidence of these complicated pregnancies seems to occur extremely rarely. Case presentation: Here, we presented a 26-year-old woman, nulli gravida with the first presentation intrauterine co...

From the published data, the present mini-review attempts to answer two fundamental questions about the gestational trophoblastic neoplasms. In addition, it extrapolates the findings to other cancers that produce small amounts of hCG and how a novel therapies could be developed.

Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted ...