Growth hormone (GH) is essential for quality of life in both children and adults, but it is also believed to enhance the growth of various neoplasms. However, the role of GH in the brain, particularly in brain tumors, has yet to be established. To clarify these problems from the perspective of receptor expression, we examined GH receptor (GHR) expression in brain tumors using immunohistochemist...

Although benign in nature, pituitary tumors continue to offer many opportunities for improvement in therapy. Goals of treatment include complete removal or ablation of tumor cells, maintenance of normal pituitary function, normalization of elevated hormone levels in endocrine-active tumors, and minimizing adverse effects from therapy. There have been many recent advances related to the surgical...

INTRODUCTION Canonical and non-canonical Wnt pathways are involved in the genesis of multiple tumors; however, their role in pituitary tumorigenesis is mostly unknown. OBJECTIVE This study evaluated gene and protein expression of Wnt pathways in pituitary tumors and whether these expression correlate to clinical outcome. MATERIALS AND METHODS Genes of the WNT canonical pathway: activating l...

background & importance: the aim of this study was to demonstrate the result of transsphenoid microsurgery for cushing disease in our center and comparing the results in details with other articles, to achieve the best decision for patients management in future. case presentation: between 1991 to 2015, 50 patients suffering from cushing disease were operated. before operation, endocrine tests a...

Irradiation of the head and neck with 800 r induced pituitary tumors in twenty of 27 female W/Fu rats (74 per cent). Three of these primary tumors were transplanted. The anatomic findings in the tumor-bearing rats indicated that these were mammosomatotropic. In addition, three mammary tumors, one osteogenic sarcoma, and one sebaceous gland carcinoma occurred in the irradiated area and none else...

Abstract Pituitary carcinomas are rare malignant neoplasms and rarely result in a solitary spinal metastasis. In this report we describe case of pituitary carcinoma that metastasized to the canal nerve roots at numerous levels, mimicking neurofibromatosis spine. This patient is 72 year old right-handed female with past medical history adenoma which was resected 5 years prior stable on imaging. ...

BACKGROUND The aim of this study was to detect the expression of cold-inducible RNA-binding protein in pituitary adenoma and to determine its effects on tumor recurrence. MATERIAL/METHODS We collected a total of 60 post-op samples collected from pituitary adenoma patients (including 20 cases of invasive pituitary adenoma, 20 cases of non-invasive adenoma, and 20 cases of non-invasive recurren...

The co-occurrence of two or more brain tumors with different histological features is rare. The authors report three rare cases of intracranial tumors associated with pituitary adenomas. Two of the pituitary tumors were functioning adenomas: a prolactinoma and a thyrotropin secreting adenoma. Two of the associated intracranial neoplasms were gliomas and one was a meningioma. Radiological and cl...