Purpose of the study . Was to analyze changes in pathophysiological parameters transplantable tumor growth and functional activity hypothalamic-pituitary-thyroid axis (HPT) rats both sexes with Guerin's carcinoma presence induced hypothyroidism. Materials methods The dynamics average life span were assessed white alley Guerins transplanted subcutaneously on background thyreostatic RIA (radioimm...

GH has diverse biological actions that are mediated by binding to a specific, high-affinity cell surface receptor (GHR). Expression of GHR is tissue specific and a requirement for cellular responsiveness to GH. IGF-I is produced in multiple tissues and regulated in part by GH through GHR. In this study, we evaluated GHR and IGF-I mRNA expression in pituitary gland and compared the levels with t...

To improve the radiologic recognition of pituitary microadenomas that have subtle or no mass effect, the appearance of the normal pituitary gland on computed tomographic (CT) images was studied. Thirteen autopsy specimens of the pituitary gland and sella turcica were examined by coronal CT and histologically sectioned in similar coronal planes. The CT and histologic findings were correlated, th...

The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of multiple signaling transduction pathways and transcriptional regulatory networks that cooperate for hormone secretion, cell plasticity, and ultimately specific pituitary respo...

Coronal computed tomographic scans of the pituitary gland in 27 normal children, adolescents, and young adults (ages, 8-21 years) and in a comparison group of adults (ages, 24-91 years) were evaluated retrospectively to test the applicability of published criteria for size and configuration of normal adult pituitary glands to younger patients. Statistically significant differences were found be...

Pituitary adenomas (Pic. 1) are a category of tumors with a high degree of diversity that occur in the central regulatory organ pituitary, which plays important roles in the hypothalamus–pituitary-targeted organ axis systems (set of direct influences and feedback interactions among hypothalamus and pituitary gland) that impact on important physiological functions of human body. Hormones secrete...

abstract men-i is a rare genetic disorder classically characterized by a predisposition to tumors of the parathyroid glands, anterior pituitary gland, and pancreatic islet cells. we present a case of men-i syndrome diagnosed using predominantly nuclear medicine imaging followed by radionuclide therapy, thus emphasizing the role of nuclear imaging in diagnosing and treating men-i.