*Correspondence: Ryan A. York, Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA e-mail: [email protected]; J. Todd Streelman, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332-0230, USA e-mail: todd.streelman@ biology.gatech.edu Despite considerable research, we still know little about th...

Although alternative splicing has been shown to give rise to isoforms of a number of transcription factors, such isoforms have not previously been detected for the POU homeodomain protein Pit-1. Screening of a rat pituitary GH3 cell cDNA expression library yielded a clone, termed pCMVPit-1a, encoding a 35.8 kD protein (Pit-1a) containing a 26 amino acid insert in the Pit-1 trans-activation doma...

The extremophilic microbes of the Berkeley Pit Lake are a valuable source of new and interesting secondary metabolites. It is of particular interest that these acidophilic microbes produce small molecule inhibitors of pathways associated with low pH and high Eh. These same small molecules also inhibit molecular pathways induced by reactive oxygen species (ROS) and inflammation in mammalian cell...

A revision of the genus Leptoplana Ehrenberg, 1831 in the Mediterranean basin is undertaken. This revision deals with the distribution and validity of the species of Leptoplana known for the area. The Mediterranean sub-species polyclad, Leptoplana tremellaris forma mediterranea Bock, 1913 is elevated to the specific level. Leptoplana mediterranea comb. nov. is redescribed from the Lake of Tunis...