Conventional drug design embraces the "one gene, one drug, one disease" philosophy. Nowadays, new generation of anti- cancer drugs, able to inhibit more than one pathway, is believed to play a major role in contemporary anticancer drug research. In this way, polypharmacology, focusing on multi-target drugs, has emerged as a new paradigm in drug discovery. A number of recent successful drugs hav...

Over the past years, several lines of evidence support an antitumourigenic effect of cannabinoids including Δ(9)-tetrahydrocannabinol (Δ(9)-THC), synthetic agonists, endocannabinoids and endocannabinoid transport or degradation inhibitors. Indeed, cannabinoids possess anti-proliferative and pro-apoptotic effects and they are known to interfere with tumour neovascularization, cancer cell migrati...

The investigation of the anticancer drugs will be important because of the proliferation ofcancer. We want to take steps to improve public health. The combination of two carbon nanotubes (singlewall nanotube and multi-wall nanotube) and Sup90-Dota (an anticancer drug) was investigated basedon Molecular Mechanic and Semi-Empirical methods. Our goal is to investigate the transfe...

One of the most important challenges in fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by ABCB1 gene many organs, one factors involved development P-gp mainly efflux toxic substances such as xenobiotics from cell. In addition to these, it also plays a role drugs used treatment cancer, rate success reduces. Phenolic compounds are chemicals that naturally synthes...

During the last decade, the application of nanotechnologies for anticancer drug delivery has been extensively explored, hoping to improve the efficacy and to reduce side effects of chemotherapy. The present review is dedicated to a certain kind of anticancer drug nanovectors developed to target tumors with the help of an external magnetic field. More particularly, this work treats anticancer dr...

There is no personalized anticancer treatment without individualized dosing. Clearly, BSA-based chemotherapy dosing does not improve the substantial pharmacokinetic variability of individual drugs. Similarly, the new oral kinase inhibitors and endocrine compounds exhibit a marked pharmacokinetic variability due to variable absorption, hepatic metabolism and potential drug-drug and food-drug int...

The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemia and in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, the frequency and thermochemical propertie...

OBJECTIVE The compensation scheme for adverse drug reactions in Japan was implemented more than three decades ago as relief system by regulatory agencies. Because of the high frequency of adverse drug reactions, anticancer drugs have been excluded from coverage by the relief system since its implementation. Requests have recently been made by some patient advocates for the expansion of relief c...

Cancer is an abnormal growth of cells which could spread in the body. Cancer is one of the common diseases in the world and chemotherapy is one of the best methods for cancer treatment. There are various types of anticancer drug that uses for chemotherapy. Doxorubicin (DOX) is one the common anticancer drug which widely uses for breast cancer. This anticancer drug has many side effects [1]. Des...