1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that selectively damages dopaminergic neurons in the substantia nigra pars compacta and induces Parkinson's like symptoms in rodents. Quercetin (QC) is a natural polyphenolic bioflavonoid with potent antioxidant and anti-inflammatory properties but lacks of clinical attraction due to low oral bioavailability. Piperine is a well ...

Hydroxypropyl starch was synthesized by modified sago starch with hydroxypropylation reaction. Hydroxypropyl starch nanoparticles with mean particle sizes of 110 nm are obtained by controlled precipitation through the drop-wise addition of dissolved hydroxypropyl starch solution into excess absolute ethanol. Piperine was loaded onto hydroxypropyl starch nanoparticles and native starch nanoparti...

A simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The method involves extraction of the fruit powder with glacial acetic acid, from which piperine is partitioned into chloroform and subsequently crystallized. The identity of the compound was confirmed by its melting point, comparison of IR, HNMR, XRPD, mass spectral and molecu...

Piperine is a type of bioactive compound that can be isolated from black pepper. Currently the utilization piperine dominated by health sector. In this study, was using Soxhlet method. The purpose research to propose mathematical model determine value diffusivity (DA) piperine, extraction rate constant (k) and isolation equilibrium for commercial designs. Based on results obtained DA at 0.1878 ...

The medicinal properties of Curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the lover and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of Curcumin in rats and healthy human volunteers. When Curcumin was g...

OBJECTIVE The objective of this study was to evaluate the nephroprotective potential of resveratrol and piperine at same dose on cationic bovine serum albumin (cBSA) induced immune complex glomerulonephritis (ICGN) in BALB/c mice. MATERIALS AND METHODS Female BALB/c mice were divided into five groups. Group I served as normal control (complete Freund's adjuvant + Saline). Two weeks later, Gro...

Citation: Chen X, Ge F, Liu J, Bao S, Chen Y, Li D, Li Y, Huang T, Chen X, Zhu Q, Lian Q and Ge R-S (2018) Diverged Effects of Piperine on Testicular Development: Stimulating Leydig Cell Development but Inhibiting Spermatogenesis in Rats. Front. Pharmacol. 9:244. doi: 10.3389/fphar.2018.00244 Diverged Effects of Piperine on Testicular Development: Stimulating Leydig Cell Development but Inhibit...

Bioactive compounds like piperine (alkaloids) offer a variety of health benefits due to their biological and pharmacological potential. Piperine has been revealed have anti-inflammatory, anti-aging, anti-diabetes, anti-bacterial, anti-ulcer, anti-carcinogenic characteristics. Recent research conducted extract using effective environmentally friendly techniques. In this study, we sought assess t...

A simple, rapid and precise spectrophotometric method has been developed for the estimation of piperine in Ayurvedic formulation Chitrakadi Vati. Three marketed preparations of Chitrakadi Vati containing black pepper (Piper nigrum) and pippali (Piper longum) from different manufacturer (CV-1, CV-2 and CV-3) were taken in this study to estimate the % w/w of piperine. The % w/w content of piperin...