PURPOSE Piperine, a major alkaloid of black pepper (Piper nigrum) and long pepper (Piper longum), was shown to have anti-inflammatory activity through the suppression of cyclooxygenase (COX)-2 gene expression and enzyme activity. It is also reported to exhibit anti-platelet activity, but the mechanism underlying this action remains unknown. In this study, we investigated a putative anti-platele...

Piperine is a major pungent substance and active component of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). Regarding the variable biological activities of piperine, it is important to study its antimutagenic activity in somatic and germ cells in vivo. Swiss albino male mice were orally administered piperine at the doses of 5, 10 and 15mg/kg b. wt. for three consecutiv...

l,2Methylenedloxy-6-methyl-4H-dibenzo [de,g] quinoline -4,5(6H)-dione together with 5-hydroxy-4',7-dimethoxyflavone; /J-sitosterol, stigmasterol and esters from the lauric and stearic acids, were isolated from the stem of Piper manausense Yunk (Piperaceae). INTRODUCCIÓN Aporphine alkaloids have been studied extenslvely because these compounds are of pharmacological significant importance (1). T...

Phytochemical study on the methanolic extract of aerial parts this plant led to isolation 7 phenolic compounds (1-7), including 3 new ones (1-3). Their chemical structures were determined be (7,8- threo)-1 -O-β-D-[6′ -O-syringoylglucopyranosyl]-2-methoxy-7,8,9-trihydroxyphenylpropane (1), threo)-8 -O-(2′′-methoxyacetophenone-1′′-yl)-1 -O-β-D-glucopyranosyl-2-methoxy-7,9-dihydroxyphenylpropane (...

Novel polyherbal formulation (PHE) containing mainly the ethanolic extract of Adhatoda vasica Nees. (leaf), Clerodendrum serratum Linn. (root), Curcuma longa Linn. (rhizome), Solanum xanthocarpum Schrad & Wendl. (fruit) and Piper longum Linn. (fruit). HPTLC analysis of the herbal extracts of PHE revealed presence of 0.25%w/w vasicine, 3.4%w/w piperine, 1.56%w/w curcumin and 0.04%w/w solasodine....

Ionizing radiations produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiations enormously. There is a need to protect humans against such effects of ionizing radiation. Attempts to protect against the deleterious effects of ionizing radiations by pharmacological intervention were made as early as 1949 and effor...

Piperlongumine (PL), a natural alkaloid from Piper longum L., possesses the highly selective and effective anticancer property. However, the effect of PL on ovarian cancer cells is still unknown. In this study, we firstly demonstrate that PL selectively inhibited cell growth of human ovarian cancer cells. Furthermore, PL notably induced cell apoptosis, G2/M phase arrest, and accumulation of the...

Amalakyadi churna is an Ayurvedic formulation, which is extensively used in traditional system of Indian medicine and by folk practitioner for treating all types of fever, and other common ailments In this study, an equal concentration of ethanolic extracts of Amalakyadi churna and its ingredients (50μg/ml of artificial sea water) were subjected to a bioscreening study to detect the cytotoxic a...

The effects of four alkaloids on the biosynthesis of ochratoxin A (OTA), ochratoxin B (OTB) and citrinin were examined on four OTA-producing aspergilli: Aspergillus auricomus, A. sclerotiorum and two isolates of A. alliaceus. Piperine and piperlongumine, natural alkaloids of Piper longum, significantly inhibited OTA production at 0.001% (w/v) for all aspergilli examined. Piperine and piperlongu...