fault tree analysis (fta) as a probabilistic risk assessment (pra) method is used to identify basic causes leading to an undesired event, to represent logical relation of these basic causes in leading to the event, and finally to calculate the probability of occurrence of this event. to conduct a quantitative fta, one needs a fault tree along with failure data of the basic events (bes). someti...

The methodology for testing pipeline steels is suggested on the assumption that destruction of pipes in field oil pipelines by mechanism grooving corrosion simultaneous fulfillment such conditions as occurrence scratches lower generatrix pipe, eventually growing into a channel form groove, emulsion enrichment with oxygen, presence pipe wall metal stressed state, chlorine-ion oil-water required....

Free-span occurs normally in a pipeline at uneven seabed, dynamic seabed and pipeline crossing. Free spanning in pipeline causes Vortex Induced Vibration (VIV) fatigue, fracture and bursting. In this paper, a pipeline located in South Pars Gas Field is assessed against local buckling and VIV fatigue using probability of failure theory based on the recommended methodology by Det Norske Veritas (...

A model is constructed for risk management of crude pipeline subject to rupture on the basis of a methodology that incorporates structured expert judgment and analytic hierarchy process AHP . The risk model calculates frequency of failure and their probable consequences for different segments of crude pipeline, considering various failure mechanisms. Specifically, structured expert judgment is ...

The antibacterial therapeutic area has been described as the perfect storm. Resistance is increasing to the point that our hospitals encounter patients infected with untreatable pathogens, the overall industry pipeline is described as dry and most multinational pharmaceutical companies have withdrawn from the area. Major contributing factors to the declining antibacterial industry pipeline incl...

The emergence of antibiotic resistance in human pathogens has become a major threat to modern medicine. The outcome of antibiotic treatment can be affected by the composition of the gut. Accordingly, knowledge of the gut resistome composition could enable more effective and individualized treatment of bacterial infections. Yet, rapid workflows for resistome characterization are lacking. To addr...

Pipeline systems are vital infrastructure to national economy, and are widely used for transporting liquid and gas matter, such as oil, natural gas, water and chemic materials. However, effective and efficient management of pipeline systems are challenging, due to its mere lengths and the diverse deployment environments. Wireless sensor network (WSN) consists of a large number of sensors, which...

Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a large-scale pooled shRNA screen in mouse embryonic stem cells (ESCs) to discover genes associated with oxidative stress resistance and found several candidates. We then developed a bioinformatics pipeline to prioritize...