The ethanolic extract of Pleurotus florida was studied for its free radical scavenging property on different in vitro models like 1,1 -diphenyl-picryl hydrazyl (DPPH)Assay, Ferric Reducing Antioxidant Power (FRAP) assay and in vitro antilipidperoxidative assay using goat liver homogenate and RBC Ghost model. The in vitro Lipid peroxidation (LPO) was inhibited to a good extent by the Pleurotus f...

In the present study, we aimed to investigate the immunosuppressive activity of vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, on T lymphocytes both in vitro and in vivo, and further explored its potential molecular mechanism. Resveratrol had a wide spectrum of healthy beneficial effects with multiple targets. Interestingly, its tetramer, vaticaffinol, exerted more inten...

We established a novel allergic dermatitis model in mouse ear lobes in which antigen-nonspecific inflammation was induced by painting 12-O-tetradecanoylphorbol 13-acetate (TPA) between sensitization and challenge with picryl chloride (PiCl). This model has an advantage for analyzing atopic dermatitis-like inflammation within a short period. Analysis of the time course changes in the PiCl-induce...

In experimental work on sensitization with a group of simple chemical substances, strong evidence was obtained for the view that the production of hypersensitivity depended upon the formation of antigenic combinations in the body (1). As a corollary, the direct administration of in vitro conjugates in these cases should lead to skin sensitivity towards the corresponding low molecular substance....

Superelectrophilic 7-chloro-4,6-dinitrobenzofuroxan (DNBF-Cl) and 7-chloro-4,6-dinitrobenzofurazan (DNBZ-Cl) are shown to undergo facile carbon-carbon couplings with a series of weak carbon nucleophiles consisting of a number of differently substituted indoles, 1,2,5-trimethylpyrrole and azulene, in acetonitrile. Despite the fact that steric effects preclude a coplanarity of the donor and accep...

Si-Wu-Tang (SWT), a traditional Chinese formula, has been clinically used in the treatment of cutaneous pruritus, chronic inflammation, and other diseases. The present study was carried out to observe the antipruritic and antiinflammatory effects of SWT aqueous extract using compound 48/80 and picryl chloride (PC) models in mice. SWT (500, 1000 mg/kg p.o.) clearly reduced the scratching respons...

The anti-ulcerative and antioxidant potentials of Egyptian propolis alcoholic extract as well as its total phenolic and flavonoid contents were evaluated. The content of total phenols and flavonoids of propolis extract were determined by spectrophotometric methods with an FC reagent and by the complexation reaction with aluminium chloride, respectively. The antioxidant activity was examined wit...

Purpose: Indigofera tinctoria Linn. of the Fabaceae family is claimed to be useful in the treatment of a variety of epileptic disorders in Indian traditional system of medicine. The present study was designed to verify this claim. Methods: Status epilepticus was induced in male albino rats of Wistar strain by administration of pilocarpine (30 mg/kg, i.p.) 24 h after injection of lithium chlorid...

Exposure to ultraviolet-B radiation impairs cellular immune responses. This immunosuppression seems to be associated with Langerhans cell migration. DNA damage appears to play a key role because enhanced nucleotide excision repair, a pathway essential for elimination of ultraviolet-B-induced DNA lesions, strongly counteracts immunosuppression. To determine the effect of DNA repair on ultraviole...

BACKGROUND Although histamine H1 receptor (H1R) antagonists are commonly used to treat atopic dermatitis, the treatment is not always effective. The histamine H4 receptor (H4R) was recently described as important to the pruritus in dermatitis. Here, we investigated whether the combination of a H1R antagonist plus a H4R antagonist attenuates chronic dermatitis in NC/Nga mice. METHODS Chronic d...