During the late summer and early fall of 1997 and 1998 heavy mortalities were detected in the carpet-shell clam Ruditapes decussatus cultured in Galicia (NW Spain). The prevalences and intensities of the parasites found in the histopathological studies were not high enough to explain the high mortality rates. Unenveloped virus-like particles were detected by transmission electron microscopy in ...

To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornaviridae family of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, in...

Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is ...

While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates that some picornaviruses hijack autophagy in order to induce autophagosome-like membrane structures for genomic RNA replication. Expression of picornavirus proteins can specifically induce the machinery of autophag...

A hepatite é uma infecção viral em que o agente causador da doença um vírus família Picornaviridae cujo gênero Hepatovírus, a mesma forma mais frequente dentre as hepatites virais, comumumente conhecida desde de meádos do século XVIII. Seu RNA possui fita simples, e considerado ultramicroscópio, infecta seletiva os humanos. Sua transmissibilidade acontece por via fecal- oral, através água alime...

Foot-and-Mouth Disease Virus (FMDV) is a member of the Picornaviridae family of viruses, which includes viruses that cause a number of high consequence human and animal diseases in addition to Foot-and-Mouth Disease (FMD), such as hand-foot-and-mouth disease, herpangina, polio, and encephalomyocarditis. FMDV infects domestic and wild cloven-hoofed animals, including bovine, caprine, ovine and s...