Both bethanechol and physostigmine produced dose-dependent negative chrono-, dromo- and inotropic effects in the dog isolated atrial preparation. Within a relatively small dose of bethanechol and physostigmine, negative inotropic effect was clearly induced but no significant chrono- and dromotropic changes were observed. With a relatively large dose, the two cholinomimetics caused negative chro...

The fact that mecamylamine is a secondary amine with “nicotinic” blocking properties suggested it would act at the Golgi recurrent collateral-Renshaw-cell synapse in the spinal cord. Glass micropipettes were used to obtain extracellular Renshaw-cell discharges due to antidromic ventral root stimulation in cats anesthetized with pentobarbital. The effects of mecamylamine, hexamethonium, physosti...

Using the hypoxic (FiO2 = 0.05) mouse model as originally described, the survival time following pretreatment with physostigmine was examined. The maximum increase in survival time was 87% following a physostigmine dose of 0.4 mg/kg. This increase was considerably less than that previously reported for this drug in a hypoxic mouse study wherein the standard method for exposing mice to hypoxia w...

EFFECTOF COLD STRESS ON GLYCOGEN AND CHOLINESTERASE CONTENTS OF RAT MYOCARDIUM AND ITS MODIFICATION BY PHYSOSTIGMINE * By V.N. SHARMA AND N.K. KHANNA *'" Department of Pharmacology and Experimental Therapeutics, S.M.S. Medical College, Jaipur. A marked depletion of myocardial glycogen occurs under different stressful situations 4,5,11, 13, 14). There is a rise in acetylcholine content of rat my...

Although fasting induces hepatic triglyceride (TG) accumulation in both rodents and humans, little is known about the underlying mechanism. Because parasympathetic nervous system activity tends to attenuate the secretion of very-low-density-lipoprotein-triglyceride (VLDL-TG) and increase TG stores in the liver, and serum cholinesterase activity is elevated in fatty liver disease, the inhibition...