نتایج جستجو برای: photoreactivation
تعداد نتایج: 311 فیلتر نتایج به سال:
Induction and Persistence of Pyrimidine Dimers in the Epidermal DMA of Two Strains of Hairless Mice1
cent sun lamp (280 to 400 nm), respectively. Enzymatic photoreactivation with yeast photoreactivating enzyme showed that -80% of the endonuclease-sensitive sites were cyclobutyl pyrimidine dimers. In both strains of mice the pyrimidine dimers remained in high-molecular-weight DNA for 24 hr after irradiation. These data show that mouse epi thelial cells in vivo have little or no capacity for the...
The photolyase gene from Thermus thermophilus was cloned and sequenced. The characteristic absorption and fluorescence spectra of the purified T. thermophilus photolyase suggested that the protein has flavin adenine dinucleotide as a chromophore. The second chromophore binding site was not conserved in T. thermophilus photolyase. The purified enzyme showed light-dependent photoreactivation acti...
Kelner (1949a) first reported that mutations to phage resistance induced in Escherichia coli by ultraviolet light could be reversed by immediate irradiation with white light. In addition he noted that end-point mutations in contrast to zero-point mutations were not reversed by visible light (1949b). At the same time Novick and Szilard (1949) reported that light-reactivation of E. coli reduced t...
Photolyase absorbs blue light and employs the energy to remove UV-induced DNA damage, cyclobutane pyrimidine dimers, or pyrimidine pyrimidone (6-4) lesions. These enzymes have been found in many living organisms ranging from bacteria to aplacental mammals, but their photoreactivation effect, such as survival increase of UV-irradiated cells by light-illumination, has not been identified in place...
UV radiation induces two major classes of pyrimidine dimers: the pyrimidine [6-4] pyrimidone photoproduct (6-4 product) and the cyclobutane pyrimidine dimer (CPD). Many organisms produce enzymes, termed photolyases, that specifically bind to these damage products and split them via a UV-A/blue light-dependent mechanism, thereby reversing the damage. These photolyases are specific for either CPD...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید