Phosphate retention and, later, hyperphosphatemia are key contributors to chronic kidney disease (CKD)-mineral and bone disorder (MBD). Phosphate homeostatic mechanisms maintain normal phosphorus levels until late-stage CKD, because of early increases in parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23). Increased serum phosphorus, and these other mineral abnormalities, individ...

In the context of the European Water Framework Directive, we studied the possible impact of reduced emissions on phosphorus and nitrogen concentrations in a lowland river-lake system (Havel River, Germany). As a prerequisite, we quantified the retention of nutrients in the river from mass balances and deduced its seasonal variation. We detected that about 30% of the total nitrogen input is reta...

This study is an attempt to correlate adrenocortical hormonal activity with various cell fractions obtained by homogenization and differential centrifugation of bovine adrenocortical tissue. Bioassays involving the decrease in circulating eosinophils and sodium retention were employed for the estimation of the glucocorticoids and mineralocorticoids respectively. The supernatant was the most act...

The phosphonate-phosphate rearrangement is an isomerisation of α-hydroxyphosphonates bearing electron-withdrawing substituents at the α-carbon atom. We studied the stereochemical course of this rearrangement with respect to phosphorus. A set of four diastereomeric α-hydroxyphosphonates was prepared by a Pudovik reaction from two diastereomeric cyclic phosphites. The hydroxyphosphonates were sep...

Impact of phosphorus control measures on in-river phosphorus retention associated with point source pollution B. O. L. Demars, D. M. Harper, J.-A. Pitt, and R. Slaughter The Macaulay Institute, Craigiebuckler, Aberdeen AB15 8QH, United Kingdom Department of Biology, University of Leicester, Leicester LE1 7RH, United Kingdom Environment Agency, Station Road, Haddiscoe, Gt Yarmouth, Norfolk, NR31...

We studied the role of phosphorus retention in parathyroid cell proliferation and parathyroid hormone (PTH) oversecretion in severe secondary parathyroid hyperplasia. Mice transplanted with human parathyroid tissue from a patient who had undergone parathyroidectomy for severe secondary hyperparathyroidism were divided into four groups; each group was given a diet with a different phosphorus con...

Adenosine 5'-(S)-[16O,17O,18O]phosphate was pyrophosphorylated by the combined action of adenylate kinase and pyruvate kinase. The isotopomers of adenosine 5'-[alpha-16O,17O,18O]triphosphate were hydrolysed by venom 5'-nucleotide phosphodiesterase (Crotalus adamanteus) in H2(17)O. Analysis by 31P nuclear magnetic resonance spectroscopy of the resulting adenosine 5'-[16O,17O,18O]phosphate, after...

Lake Okeechobee, Florida, USA, currently is threatened by phosphorus (P) loading from the adjacent watershed north of the lake. The primary land uses in the watershed are beef cattle ranching and dairy farming for which there is a high net P import. The upland soils are predominantly poorly-drained, sandy Spodosols. Although the soils have low P retention capacity, about 80% of the applied P ha...