Fosfomycin, [L-(cis)-1, 2-epoxypropyl phosphonic acid] (FOM), a broad spectrum antibiotic produced by some strains of Streptomyces species1), acts as a phosphoenolpyruvate analog and irreversibly inhibits phosphoenolpyruvate UDP-N-acetylglucosamine (UDPG1cNAc)-3-O-enolpyruvyl transferase, an enzyme which catalyzes the first step of peptidoglycan biosynthesis2). FOM enters susceptible bacteria b...

Size selective growth of palladium nano-particles 2-7 nm in diameter on the surface of carbon nano-onions (CNOs) (derived from catalytic cracking of methane) in water involves pretreating the CNOs with p-phosphonic acid calix[8]arene then H(2)PdCl(4) followed by dynamic thin film processing under hydrogen in a vortex fluidic device.

The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking the O-tosyl group had improved STAT-3 inhibitory activity. The equivalent potencies observed by the replacement of phosphonic acid moiety of 1...

Optically active 1,2-bis(alkylmethylphosphino)ethanes and bis(alkylmethylphosphino)methanes are unique diphosphine ligands combining the simple molecular structure and P-stereogenic asymmetric environment. This work shows that these ligands exhibit excellent enantioselectivity in rhodium-catalyzed asymmetric hydrogenation of , -unsaturated phosphonic acid derivatives. The enantioselective hydro...

p-Phosphonic acid calix[4]arenes render high stability to exfoliated graphenes in water. These calix[4]arenes modified graphenes can be used as highly effective substrates to nucleate ultra-small Pd nanoparticles, which in turn serve as galvanic reaction templates for the generation of high density 2D arrays of Pt nanoparticles.

Oligophosphonic and -phosphinic acids roused significant interest as complexing agents and gained importance in many fields of practical chemistry. Particular attention was drawn towards molecules having two or more phosphonic or phosphinic acid substituents in vicinal and/or preferably geminal positions attached to the ethane fragment. Novel synthetic procedures [1 -4 ] led to structures relat...

The example of phase transformation from a centrosymmetric space group at low temperature (LT) to a chiral space group at high temperature (HT) is reported, which was clearly resolved in a single-crystal-to-single-crystal manner in a 3D uranyl(vi) phosphonate compound [TMA][(UO2)2(1,3-pbpH)(1,3-pbpH2)] () (TMA(+) = tetramethylammonium cation; 1,3-pbpH4 = 1,3-phenylenebis(phosphonic acid)).

In situ sonic probe exfoliated graphene sheets in the presence of various concentrations of p-phosphonic acid calix[8]arene are effective in removing nitrate from aquatic effluents, with the efficiency increasing for higher ratios of calixarene to graphite. Mild sonication of the nitrate-adsorbed material releases some nitrate ions back to the effluent.