BACKGROUND In the brain, processing of fearful stimuli engages the amygdala, and the variability of its activity is associated with genetic factors as well as with emotional salience. The objective of this study was to explore the relevance of personality style for variability of amygdala response. METHODS We studied two groups (n=14 in each group) of healthy subjects categorized by contrasti...

Specific phobias are among the most common psychological problems (Kessler et al. 2005); however, specific phobias are seldom the primary reason that individuals seek treatment (Brown et al. 2001b). Because specific phobias are rarely the focus of clinical attention, there is a common—though in many cases mistaken—perception that specific phobias are straightforward and uncomplicated. In additi...

The current study examined the role of thought suppression in spider phobia. Spider phobic (n = 41) and non-phobic (n = 40) subjects were asked to monitor their thoughts for three 5 min periods. During the first period, all subjects were instructed to "think about anything". During the second period, half of the subjects received suppression instructions (i.e., subjects were explicitly asked "n...

The electrocortical correlates of the processing of feared/fear-relevant and neutral stimuli were investigated in a pictorial emotional Stroop paradigm with spider phobic, social phobic, and nonphobic subjects. Subjects identified either the color of red or blue pictures of spiders, birds, or flowers (emotional Stroop task) or the object itself (identification task) by pressing different button...

Recently, a differential recruitment of brain areas throughout the distributed neural system for face perception has been found in social phobic patients as compared to healthy control subjects. These functional abnormalities in social phobic patients extend beyond emotion-related brain areas, such as the amygdala, to include cortical networks that modulate attention and process other facial fe...

BACKGROUND AND OBJECTIVES Psychological distress has been hypothesized to be associated with adverse biologic states such as higher oxidative stress and inflammation. Yet, little is known about associations between a common form of distress - phobic anxiety - and global oxidative stress. Thus, we related phobic anxiety to plasma fluorescent oxidation products (FlOPs), a global oxidative stress ...

Rapid response to danger holds an evolutionary advantage. In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed awareness or not of either phobic, fear-relevant (e.g., spiders to snake phobics), or neutral images. When the timing did not permit awareness, the amygdala responded to both phobic and fear-relevant stimuli. With ti...

Purpose Anxiety-related problems at work are a serious problem in the occupational context, as they come along with sick leave and problems in work participation. The aim of this study is to analyse workplace phobic anxiety in nonclinical context using the Job Demands-Resources model. Methods The study involved a sample of 739 workers from a retail company, mostly with permanent contracts. St...