Pharmacovigilance and methods of Signal Detection

The goal of pharmacovigilance is to detect, monitor, characterize and prevent adverse drug events (ADEs) with pharmaceutical products. This article is a comprehensive structured review of recent advances in applying natural language processing (NLP) to electronic health record (EHR) narratives for pharmacovigilance. We review methods of varying complexity and problem focus, summarize the curren...

Adverse drugs events (ADEs) detection constitutes a considerable concern in patient safety and public health care. For this reason, it is important to develop methods that improve ADE signal detection in pharmacovigilance databases. Our objective is to apply 3D pharmacophoric similarity models to enhance ADE recognition in Offsides, a pharmacovigilance resource with drug-ADE associations extrac...

The objective of this study was to apply 2 data-mining algorithms to a drug safety database to determine if these methods would have flagged potentially fatal/disabling adverse drug reactions that triggered black box warnings/drug withdrawals in advance of initial identification via "traditional" methods. Relevant drug-event combinations were identified from a journal publication. Data-mining a...

OBJECTIVES While active surveillance for adverse drug events using electronic medical records (EMRs) and claims data is expanding, these data do not fully capture patient experiences with medication-related symptoms. Our objective was to describe adherence and outcomes associated with an automated pharmacovigilance call. STUDY DESIGN/METHODS Prospective cohort of patients receiving a prescrip...

This paper summarizes the first year of activity of the Ceará State Pharmacovigilance System (SIFACE) as a strategy to discuss practical and methodological problems related to developing pharmacovigilance in Brazil. Siface is being structured by the Group for the Prevention of Improper Use of Pharmaceuticals (GPUIM), based on hospital pharmacies. A total of 63 reports (119 suspected adverse dru...

UNLABELLED Analyzing the pattern and quality of scientific communications on pharmacovigilance can help the regional centers in Nepal and other developing countries to develop approaches for communicating effectively medicine safety issues. This kind of research is lacking in developing countries. OBJECTIVES To analyze the pattern and quality of scientific communications on drug safety produc...

IJMDS ● www.ijmds.org ● July 2017; 6(2) 1498 Original Article Assessment of knowledge, attitude and practice of Pharmacovigilance among the interns in a tertiary care hospital in northern IndiaA questionnaire based study Garg P, Sharma V, Bajaj JK ABSTRACT Background: The use of drugs and occurrence of its ADRs go hand in hand. Spontaneous reporting of ADRs is an effective method and needs to b...

Objective: To assess awareness of pharmacovigilance among the healthcare professionals and to evaluate the impact of an educational intervention for improving awareness of pharmacovigilance among physician, pharmacist and nurses in an Indian tertiary care teaching hospital. Material &Methods: A suitable self-administered Knowledge, attitude, practice (KAP) survey questionnaire was designed, val...

Pharmacovigilance aims to monitor drug safety using sources such as spontaneous reporting systems, biomedical literature or electronic health record data. Clinical trials represent a source of drug-event pairs data complementary to these sources for signal detection in pharmacovigilance platforms. The advantage of ClinicalTrials.gov (CTG) over other pharmacovigilance sources is the large number...