Blood coagulation is the process that results in the formation of a blood clot to stop bleeding from a damaged blood vessel. Various pharmacologic agents can affect the coagulation process. The American College of Chest Physicians' evidence-based practice guidelines for perioperative management of antithrombotic therapy provide guidance for anticoagulant or antiplatelet therapy and bridge thera...

Abstract Cancer progression and the onset of therapeutic resistance are often results uncontrolled activation survival kinases. The proviral integration for Moloney murine leukemia virus (PIM) kinases oncogenic serine/threonine that regulate tumorigenesis by phosphorylating a wide range substrates control cellular metabolism, proliferation, survival. Because their broad impact on processes faci...

Recommendation 1: Clinicians should base the decision to initiate a trial of therapy with a cholinesterase inhibitor or memantine on individualized assessment. (Grade: weak recommendation, moderate-quality evidence.) Recommendation 2: Clinicians should base the choice of pharmacologic agents on tolerability, adverse effect profile, ease of use, and cost of medication. The evidence is insufficie...

Electroconvulsive therapy (ECT) is becoming increasingly popular in the treatment of medication-resistant depression. Understanding the concepts behind the physiological changes brought upon by the stimulus as well as the rationale behind the various pharmacologic agents used during the procedure is crucial in providing safe and effective ECT. This review will discuss the general principles of ...