Airaksinen, S.T.T., 2005. Role of excipients in moisture sorption and physical stability of solid pharmaceutical formulations. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki, 20/2005, pp. 57, ISBN 952-10-2733-9 (print) ISBN 952-10-2734-7 (pdf) ISSN 1795-7079 The interaction of moisture with pharmaceutical solids is crucial to an understanding of water-based pro...

double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. in this study various parameters including technical and composition...

One of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. However, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.The main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...

OBJECTIVE To explore the quality and safety of medicines in Canada. DESIGN A retrospective review of drug recalls and risk communication documents conveying issues relating to defective (ie, substandard and falsified) medicines. SETTING The Health Canada website search for drug recalls and risk communication documents issued between 2005 and 2013. ELIGIBILITY CRITERIA Drug recalls and ris...

The increasing number of challenging new chemical entities in development coupled with the pressure to reduce R&D and production costs have created the perfect storm in the pharmaceutical industry. Using a science-based approach to excipient selection will allow you to overcome challenges such as poor bioavailability and stability while optimizing the formulation using the manufacturing process...

QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include defining a target product quality profile, designing product and manufacturing processes, identifying critical quality attributes, process parameters, and sources of variability and controlling...

Not surprisingly, the wide range of effective medicinal agents available today is one of the greatest scientific achievements. Regardless of the advancements in effectiveness and safety of the medicines embedded in dosage forms, the pharmaceutical concept of the latter is growing to be ever more eminent (Adibkia et al., 2011). Following on from recent advancements, in a time of increased consid...

Hydrochlorothiazide is a diuretic used to treat hypertension that belongs to class IV of the Biopharmaceutics Classification System. The drug was evaluated by quality control, thermal characterization tests, and pharmaceutical formulation compatibility studies. It was concluded that the generic drug, Lab 2, was not a pharmaceutical equivalent. The compounded drugs, Lab 5 and Lab 6, produced uns...

century, a new era that will be far more scientific, technologic, and sophisticated than anyone would have imagined just a quarter of a century ago. However, the continued success in all areas of pharmaceutical science will depend entirely on how fast pharmaceutical scientists will adapt to rapidly changing technology. Almost 10 years ago, a survey by Shangraw and Demarest revealed a very inter...

Poor aqueous solubility of lead drug candidates remains an obstacle for drug development in pharmaceutical industries. Drugs with dissolution rate limited drug absorption show low bioavailability due to poor aqueous solubility of the drug. To overcome these problems different formulations of nanosized drugs were developed recently. Pharmaceutical nanosuspensions consist of dispersed solid drug ...