THE work described in this paper is a continuation of that commenced by H. I. Price and Lewis [1929] and extended by Jones and Lewis [1932]. The former measured, by means of a dynamic method, the surface tension of aqueous dispersions of pure lecithin as a function of PH. It was found that a maximum value of the surface tension occurred at PH 2-6 (approx.) in close agreement with the value of t...

Recently, a number of two LIM-domain containing proteins (LIMs) have been reported to trigger the formation of actin bundles, a major higher-order cytoskeletal assembly. Here, we analyzed the six Arabidopsis thaliana LIM proteins. Promoter-β-glucuronidase reporter studies revealed that WLIM1, WLIM2a, and WLIM2b are widely expressed, whereas PLIM2a, PLIM2b, and PLIM2c are predominantly expressed...

The phosphatidylinositol 3-kinase/AKT signaling pathway plays a critical role in activating survival and antiapoptotic pathways within cancer cells. Several studies have shown that this pathway is constitutively activated in many different cancer types. The goal of this study was to discover novel compounds that bind to the pleckstrin homology (PH) domain of AKT, thereby inhibiting AKT activati...

BACKGROUND Despite homeostatic pH regulation, systemic and cellular pH changes take place and strongly influence metabolic processes. Transcription of the glutamine transporter SNAT3 (Slc38a3) for instance is highly up-regulated in the kidney during metabolic acidosis to provide glutamine for ammonia production. METHODS Slc38a3 promoter activity and messenger RNA stability were measured in cu...

1. A new method has been developed for the specific extraction of histone fraction f2(a) from calfthymus deoxyribonucleoprotein at pH 7 by using a mixture of ethanol and guanidinium chloride. 2. Fraction f2(a) has been separated into the subfractions f2(a)1 and f2(a)2 by acetone precipitation from acid solution, and at pH7. 3. Modifications of existing electrophoretic methods are described that...

we had the opportunity to examine the cranium of a young woman found at the well-known neolithic site of ali koshon the deh luran plain in southwestern iran. it has previously been claimed that her head shows traces of modification,a practice which can be termed as either cultural or artificial cranial modification. here, we describe several macroscopiccharacteristics of the modified crania and...

The interfacial properties of bovine testicular hyaluronidase were investigated by demonstrating the association of hyaluronidase activity with membranes prepared from bovine testis. Protein adsorption to the air/water interface was investigated using surface pressure-area isotherms. In whichever way the interfacial films were obtained (protein injection or deposition), the hyaluronidase exhibi...

Since the preindustrial era, the average surface ocean pH has declined by 0.1 pH units and is predicted to decline by an additional 0.3 units by the year 2100. Although subtle, this decreasing pH has profound effects on the seawater saturation state of carbonate minerals and is thus predicted to impact on calcifying organisms. Among these are the scleractinian corals, which are the main builder...

in this paper we study the concept of ph-biatness ofa banach algebra a, where ph is a continuous homomorphism on a.we prove that if ph is a continuous epimorphism on a and a hasa bounded approximate identity and a is ph- biat, then a is ph-amenable. in the case where ph is an isomorphism on a we showthat the ph- amenability of a implies its ph-biatness.

The reduction of oxygen increases pH in the surroundings of an electrode. A theoretical model estimates the steady-state pH profile from the surface of the electrode up to the bulk solution. A very simple formula predicts that, in non-deaerated solutions, for bulk pH-values between 4.0 and 10.0, the corresponding surface pH could be as high as 10.3, regardless of the thickness of the diffusion ...