The Yorkshire Leukaemia Group (YLG) study was performed to determine the clinical, morphological, immunophenotypic, and genotypic characteristics of persistent large granular lymphocyte (LGL)/natural killer (NK) cell proliferations.’ The study showed that persistent LGL expansions may occur within normal white blood cell (WBC) counts and/or normal absolute lymphocyte counts. Furthermore, the ly...

The in vivo transcriptional status of bovine leukemia virus was assessed at three stages of infection during the progression of the disease: aleukemic stage, persistent lymphocytosis, and leukemia/lymphosarcoma. Bovine leukemia virus transcripts could be amplified from total or cytoplasmic enriched lymphocyte RNA by reverse transcription polymerase chain reaction in cells from all but a few ale...

Clonal expansions of CD4 positive T large granular lymphocytes with or without coexpression of CD8 are extremely uncommon. These typically display an indolent clinical course and are said to be associated with other solid malignancies. We present the clinicopathologic features and immunophenotypic analyses of two rare cases of CD4 positive T large granular lymphocyte proliferation with expressi...

Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of diseases that occur following transplantation. Large granular lymphocytic (LGL) lymphocytosis is one type of PTLD, ranging from reactive polyclonal self-limited expansion to oligo/monoclonal lymphocytosis or even to overt leukaemia. LGL lymphocytosis in transplant recipients may present as a relatively indol...

BACKGROUND Malignant thymomas are rarely associated with bone metastasis and T-cell lymphocytosis. CASE PRESENTATION A 47-year-old female patient was admitted to our hospital for ptosis. A diagnosis of malignant thymoma was made based on the thymectomy and pathological result. Peripheral T-cell lymphocytosis and bone metastasis were found later. T-cell lymphocytosis was relived after surgical...