نتایج جستجو برای: peroxynitrite

تعداد نتایج: 3024  

Journal: :American journal of physiology. Lung cellular and molecular physiology 2008
Tomohiro Ichikawa Hisatoshi Sugiura Akira Koarai Satoru Yanagisawa Masae Kanda Atsushi Hayata Kanako Furukawa Keiichiro Akamatsu Tsunahiko Hirano Masanori Nakanishi Kazuto Matsunaga Yoshiaki Minakata Masakazu Ichinose

Irreversible airflow limitation in asthma is associated with airway remodeling in which the differentiation of fibroblasts to myofibroblasts plays a pivotal role. In asthmatic airways, excessive production of reactive nitrogen species (RNS) has been observed. The aim of this study is to evaluate whether peroxynitrite, one of the RNS, can affect the differentiation of fibroblasts to myofibroblas...

2013
M. Asad Khan Kiran Dixit Zarina Arif Jalaluddin M. Ashraf Khursheed Alam

Peroxynitrite is a bifaceted reactive species. It can oxidize and nitrate proteins/nucleic acids/lipids and is involved in inflammation, apoptosis, cytotoxicity and autoimmune disorders of unknown etiology, including SLE. In this study, H3 histone exposed to peroxynitrite caused loss of tertiary structure, nitration of tyrosine residues and dityrosine formation. Experimentally produced antibodi...

Journal: :American journal of physiology. Heart and circulatory physiology 2000
W Kossenjans A Eis R Sahay D Brockman L Myatt

Oxidative stress may increase production of superoxide and nitric oxide, leading to formation of prooxidant peroxynitrite to cause vascular dysfunction. Having found nitrotyrosine residues, a marker of peroxynitrite action, in placental vessels of preeclamptic and diabetic pregnancies, we determined whether vasoreactivity is altered in these placentas and treatment with peroxynitrite produces v...

Journal: :Investigative ophthalmology & visual science 2004
Geetha Thiagarajan Jaganathan Lakshmanan Madhavilatha Chalasani Dorairajan Balasubramanian

PURPOSE . Peroxynitrite is a highly potent reactive oxygen/nitrogen species present in the environment and also endogenously in the eye, that causes a variety of disorders. This study was undertaken to look at the oxidative damage that peroxynitrite causes to the proteins of the lens and the functional consequences thereof. METHODS . Peroxynitrite was allowed to react with alpha-, beta-, and ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Yumin Zhang Hong Wang Jianrong Li Daniel A Jimenez Edwin S Levitan Elias Aizenman Paul A Rosenberg

Peroxynitrite toxicity is a major cause of neuronal injury in stroke and neurodegenerative disorders. The mechanisms underlying the neurotoxicity induced by peroxynitrite are still unclear. In this study, we observed that TPEN [N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine], a zinc chelator, protected against neurotoxicity induced by exogenous as well as endogenous (coadministration of NM...

2016
Yuliya Mikhed Kai Bruns Stefan Schildknecht Michael Jörg Mobin Dib Matthias Oelze Karl J. Lackner Thomas Münzel Volker Ullrich Andreas Daiber

There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine. Previous data showed that at nanomolar fluxes of peroxynitrite, nitration of these phenolic compounds was outcompeted by dimerization (e.g. biphenols or dityrosi...

Journal: :Journal of immunology 2002
Jon L Freels Dan K Nelson Jeffrey C Hoyt Michael Habib Hiroki Numanami R Clark Lantz Richard A Robbins

Nitric oxide and superoxide form the unstable compound, peroxynitrite, which can nitrate proteins and compromise function of proinflammatory cytokines at sites of inflammation. Reduced function of proinflammatory proteins such as IL-8, macrophage inflammatory protein-1alpha, and eotaxin suggest an anti-inflammatory effect of nitration. The effects of nitration on anti-inflammatory cytokines suc...

Journal: :American journal of physiology. Heart and circulatory physiology 2002
Karine Laude Christian Thuillez Vincent Richard

Experiments were designed to test whether nitric oxide (NO) and peroxynitrite trigger delayed coronary endothelial protection induced by preconditioning (PC) in rats. Prolonged ischemia reperfusion markedly reduced the response of isolated coronary arteries to acetylcholine, and this was prevented by PC performed 24 h earlier. The NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (...

2014
Juyoung Yoon Steven D. Bull Tony D. James Xiaolong Sun Qingling Xu Gyoungmi Kim Stephen E. Flower John P. Lowe John S. Fossey Xuhong Qian

(2014) A water-soluble boronate-based fluorescent probe for the selective detection of peroxynitrite and imaging in living cells. This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. A water-soluble boronate-based fl uorescent probe for the selective detection of peroxynitrite and imaging in living cells A water-...

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