نتایج جستجو برای: peroxisome proliferator
تعداد نتایج: 15330 فیلتر نتایج به سال:
Peroxisome proliferator–activated receptor ; (PPAR;) is known to be expressed in several cancers, and the treatment of these cancer cells with PPAR; ligands often induces cell differentiation and apoptosis. Recently, the chemopreventive potential of PPAR; ligands on colon carcinogenesis was reported, although the effect of PPAR; on colon carcinogenesis and the mechanism of the effect remain con...
Peroxisome proliferators, which function as peroxisome proliferator-activated receptor (PPAR ) agonists, induce peroxisomal, microsomal, and mitochondrial fatty acid oxidation enzymes, in conjunction with peroxisome proliferation, in liver cells. Sustained activation of PPAR leads to the development of liver tumors in rats and mice. The assertion that synthetic PPAR ligands pose negligible carc...
Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6 polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase activities. Oxylipins are involved in the development and function of adipose tissue and their productions are strictly related to diet quality and quantity. Oxylipins signal via cell surface membrane (G Protein-coupled receptors) an...
A large number of industrial chemicals and environmental pollutants, including trichloroethylene (TCE), di(2-ethylhexyl)phthalate (DEHP), perfluorooctanoic acid (PFOA), and various phenoxyacetic acid herbicides, are nongenotoxic rodent hepatocarcinogens whose human health risk is uncertain. Rodent model studies have identified the receptor involved in the hepatotoxic and hepatocarcinogenic acti...
26 Vascular endothelial cells express the ligand-activated transcription factor, peroxisome 27 proliferator-activated receptor gamma (PPARγ), which participates in regulation of 28 metabolism, cell proliferation, and inflammation. PPARγ ligands attenuate, while loss of 29 function mutations in PPARγ stimulate, endothelial dysfunction suggesting that PPARγ 30 may regulate vascular endothelial ni...
This review shows how some transcription factors respond to alterations in macronutrients. Carbohydrates induce enzymes for their metabolism and fatty acid synthesis. Fatty acids reduce carbohydrate processing, induce enzymes for their metabolism, and increase both gluconeogenesis and storage of fat. Fat stores help control carbohydrate uptake by other cells. The following main transcription fa...
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