نتایج جستجو برای: perivascular vascular adipose
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Adipose stem cells, which reside in a vascular niche, are essential to the development and maintenance of adipose tissue. Data from humans and rodents show that maintenance of adult adipose tissue is a dynamic process. Adipocyte turnover in young adult mice is estimated to be greater than 10% per month. The adipose stem cell niche is just as active, generating new adipocytes and replenishing th...
BACKGROUND AND PURPOSE We have recently shown that a reduced function of endothelial nitric oxide synthase (eNOS) in the perivascular adipose tissue (PVAT) contributes crucially to obesity-induced vascular dysfunction in mice. The current study was conducted to test the hypothesis that vascular dysfunction in obesity can be reversed by in vivo improvement of PVAT eNOS activity. EXPERIMENTAL A...
Obesity is a non-infectious pandemic. The visceral distribution of adipose tissue significant factor in the development cardiovascular diseases and their complications. Along with abdominal depot omentum subcutaneous tissue, there are other ectopic depots: epicardial (EAT), perivascular (PVAT) perirenal tissue. This article presents review physiological role molecular basis PVAT EAT function he...
KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue and that they represent novel targets to rescue periadventitial vascular dysfunction. Two m...
Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an importa...
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