We hypothesized that near-infrared spectroscopy (NIRS) measures of hemoglobin and/or myoglobin O2 saturation (IR-SO2) in the vascular bed of exercising muscle would parallel changes in femoral venous O2 saturation (SfvO2) at the onset of leg-kicking exercise in humans. Six healthy subjects performed transitions from rest to 48 +/- 3 (SE)-W two-legged kicking exercise while breathing 14, 21, or ...

Extracorporeal membrane oxygenation has been used successfully to support both cardiac and pulmonary function following Stage I Norwood operation. Determination of the return of native cardiac function and pulmonary function can be easily accomplished because of the single ventricle physiology. The pulmonary function can be assessed while on full flow ECMO by isolating the membrane oxygenator g...

The effects of intracoronary infusions of substance P in conscious humans on epicardial vessel diameter and coronary sinus oxygen saturation were investigated in 13 patients who had angiographically normal coronary arteries. The dose of substance P ranged from 2.8 to 89.6 pmol/min, starting at 2.8 pmol/min and rising by doubling increments. All infusions were performed for 2-minute periods. Epi...

BACKGROUND Vasopressor agents are commonly used to increase mean arterial pressure (MAP) in order to secure a pressure gradient to perfuse vital organs. The influence of norepinephrine on cerebral oxygenation is not clear. The aim of this study was to evaluate the impact of the infusion of norepinephrine on cerebral oxygenation in healthy subjects. METHODS Three doses of norepinephrine (0.05,...

Background—A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF). Methods and Results—We investigated the capacity for red blood cells (RBCs) to ...

BACKGROUND A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF). METHODS AND RESULTS We investigated the capacity for red blood cells (RBCs) t...

Background: establishing a regular respiratory condition in the infants is one of the basic considerations in NICU.  Newborns show noticeable breath alterations in response to even low concentrations of some fragrance. Aim: determining the effect of breast milk odor on oxygen saturation and respiratory rate in premature infants. Methods: In this four-group randomized clinical trial, 180 prematu...

Background: The pandemic situation created an overwhelmed needs for ICU facilities, according to this problem, the need of accurate the management of facilities represents bold. In this study, prognostic risk factors for ICU admission among COVID-19 hospitalized patients were evaluated. Methods: From 22 February to April 20, 2020. Totally,214 COVID-19 patients participated in this study. The i...

In the past, near infrared spectroscopy (NIRS) has been mostly used to investigate oxidative metabolism in pathophysiology (Belardinelli et al., 1995; Ferrari et al., 1997). However, its application to exercise has increased exponentially over the past 15 years. NIRS is a noninvasive optical technology used to estimate tissue oxygenation by applying the physical principles associated with light...

Raised internal pressure in a distressed submarine rapidly increases the risk of decompression sickness (DCS) following submarine escape. The hypothesis that breathing a hyperoxic gas during escape may reduce the risk of DCS was tested using goats. Shallow air saturation and simulated submarine escape dives were carried out either singularly or in combination (saturation, escape, or saturation ...