UNLABELLED Since the existence of pHp was demonstrated, it has been shown that this molecule and its receptor CD163 are regulated by different stimuli. Furthermore, a comparably fast secretion of pHp was described as well as the immuno-stimulatory effects. The intention of this study was to elucidate the role of pHp in the human lungs further. Here we show, by means of confocal microscopy and i...

Pseudohypoparathyroidism type Ia (PHP-Ia), one of 4 types of PHP, is a genetic disease characterized by clinical hypoparathyroidism caused by parathyroid hormone (PTH) resistance. In addition, patients with PHP-Ia show resistance to other hormones as well as Albright's hereditary osteodystrophy (AHO), a constellation of features including short stature, obesity, brachydactyly, ectopic ossificat...

Pseudohypoparathyroidism (PHP) refers to two major variants that generally coexist in the same family, PHP type Ia (PHP Ia), in which both PTH resistance and a constellation of physical features, termed Albright's hereditary osteodystrophy (AHO), are present, and pseudopseudohypoparathyroidism (PPHP), in which AHO occurs without PTH resistance. Most patients with PHP Ia show a partial deficienc...

Aim It was previously reported that several patients with pseudohypoparathyroidism type 1b (PHP-1b) have a more generalised imprinting defect. However there was no report that a patient of PHP-1a has any generalised imprinting defects. Here we aim to report a case of PHP-1a with hypomethylation at the Kv-differentially methylated region (DMR) (11p15.5), responsible for Beckwith-Wiedemann syndrome.

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Twenty strains (including eight phase variant pairs) of nematode-symbiotic and insect-pathogenic Photorhabdus bacteria were examined for the production of proteolytic enzymes by using a combination of several methods, including gelatin liquefaction, zymography coupled to native and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and activity measurement with two chromogen substrate t...

OBJECTIVES To analyze strategies of operative management (OM) and non-operative management (NOM), mortality, and morbidity of hepatic trauma patients. METHODS We retrospectively reviewed 296 consecutive patients with hepatic trauma at the Department of Hepatobiliary Surgery, 101st Hospital of PLA, Wuxi, Jiangsu, China a single level one trauma center between January 2003 and December 2012. Da...

A 71-year-old male patient was admitted with a diagnosis of acute myocardial infarction, he underwent an urgent coronary angiography and stent implantation to a totally occluded circumflex coronary artery. During the percutaneous coronary intervention, cardiac arrest occurred and a short-lived and successful mechanical and medical cardiopulmonary resuscitation was applied. Once a satisfactory c...

This paper demonstrates that a hydraulically acting Helmholtz resonator can exist in a piezoelectric–hydraulic pump (PHP) based hybrid actuator, which in turn affects the volumetric efficiency of the PHP. The simulation and experimental results illustrate the effect of Helmholtz resonance on the flow rate performance of the PHP. The study also shows how to shift the Helmholtz resonant frequency...