BACKGROUND AND PURPOSE Arterial spin-labeling is an emerging technique for noninvasive measurement of cerebral perfusion, but concerns remain regarding the reliability of CBF quantification and clinical applications. Recently, an ASL implementation called QUASAR was proposed, and it was shown to have good reproducibility of CBF assessment in healthy volunteers. This study aimed to determine the...

Perfusion is a fundamental biological function that refers to the delivery of oxygen and nutrients to tissue by means of blood flow. Perfusion MRI is sensitive to microvasculature and has been applied in a wide variety of clinical applications, including the classification of tumors, identification of stroke regions, and characterization of other diseases. Perfusion MRI techniques are classifie...

UNLABELLED Gated myocadial perfusion SPECT (MPS) incorporates functional and perfusion information of the left ventricle (LV). To improve the image quality and accuracy of gated MPS we propose to eliminate the influence of cardiac LV motion in the display and quantification by a novel "motion-frozen" (MF) technique. METHODS Three-dimensional LV contours were identified on images of the indivi...

Introduction: Being able to measure cerebral perfusion and cerebral blood volume quantitatively is of great importance when it comes to diagnosing and treating various cerebrovascular diseases and other brain disorders. In a clinical setting, MR perfusion imaging is normally performed using dynamic susceptibility contrast imaging. When it comes to absolute quantification, this method has severa...

Background Several studies have shown the potential of semi-quantitative and fully-quantitative analysis of cardiovascular magnetic resonance (CMR) perfusion images in the diagnosis of coronary artery disease (CAD). However, estimates of myocardial blood flow (MBF) rely on accurate selection of important timing parameters. In this study, we evaluate how the identification of the timing of the S...

Background Quantification of myocardial blood flow (MBF) using first-pass perfusion MRI has potential to objectively evaluate ischemic heart disease. While considerable development and clinical research has been conducted during the past two decades on this topic, there lacks a perfusion flow mapping solution that runs on the MRI scanner and produces MBF maps immediately following the perfusion...

An arterial spin tagging (AST) pulse sequence has been developed to measure T(1) and relative blood perfusion. This full sequence is composed of three sequences: selective tagging, nonselective tagging, and nontagging. Perfusion quantification error resulting from imperfect inversion and acquisition slice profiles has been addressed in the literature. In this work, the error is reduced through ...

Background Modern MRI myocardial perfusion protocols use rapid venous bolus injections, typically 3-5 ml/s of 5-15 ml of agent over a few seconds. The resulting arterial input functions are rapidly varying with high agent concentrations (Fig. 1A and 1B) and thus typically require high temporal resolution acquisitions (~1 sec), custom pulse sequences and complex processing methods for perfusion ...

Tissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods to measure renal perfusion remain elusive, particularly in the clinic. Arterial spin labeling (ASL...