Predicting whether T cell receptors bind to specific peptides is a challenging problem because most binding examples in the training data involve only few peptides. A new approach uses meta-learning improve predictions for which no or little exists.

Self-assemblingof peptides is a spontaneous process by which are self-organized toform well-ordered structures intramolecular and intermolecular interactions.This controlled the balance of forces (attractive andrepulsive) within peptide molecules. Notable methods used for synthesisof self-assembly solid-phase synthesis, liquid-phase synthesis,recombinant technology, use external fields. The sel...

ABSTRACT Background Antibiotic resistance makes antimicrobial peptides (AMPs) agents an alternative for treatment of pathogenic diseases. They are isolated from various animals invertebrates, vertebrates and plants. The present study shows the electrophoretic pattern of protein and peptides from Vicia Faba seed and reports our first attempt to study the antibacterial activity of Vicia faba...

Background: Xanthomonas citri subsp. citri (Xcc), the causative agent of bacterial citrus canker, has affected citriculture worldwide. Varieties of means have been used to minimize its devastating effects, but no attention has been given to bacteriocins. Objectives: Here and for the first time, we report the isolation and characterization of two novel bacteriocins. Materials and Methods: Secret...

The venom of animals, including snakes, scorpions, and spiders is a complex combination of proteins, peptides, and other biomolecules as well as some minerals. Among the biomolecules of some animal’s venom, small peptides that lack disulfide bands known as Non-Disulfide Bridge Peptides (NDBPs) potentiate the bradykinin by preventing the conversion of angiotensin 1 to angiotensin 2 using the mec...

ABSTRACT Lena Ho studied biochemistry at the University of Wisconsin–Madison, USA, funded by a scholarship from Singapore Economic Development Board. then joined lab Gerald Crabtree Stanford for her PhD, where she investigated function and mechanism chromatin remodelling proteins in epigenetic regulation embryonic, haematopoietic cancer stem cells. She moved back to postdoc Bruno Reversade's In...

Oceanic environments are one of the largest sources bioactive molecules, due to high degree biodiversity and innumerable ecological relationships established between macro microorganisms found in different ecosystems these complex environments. Marine organisms being studied increasingly because they considered important producers biologically active peptides. Peptides extracted from marine hav...

Our research group has been studying the design of intracellular delivery peptides based on cationic lytic peptides. By placing negatively charged amino acids potentially hydrophobic faces peptides, membrane activity is attenuated cell surface, whereas it recovers in endosomes, enabling cytosolic proteins including antibodies. These generally contain multiple lysines, facilitating surface inter...

objective: animal studies show that vaccination with epitope-based peptides results in protective immunity. however, immunodominance should be regarded as a major challenge in this area. considering the advantages of epitopic-vaccines against hepatitis c virus (hcv) infection, herein, we compared the occurrence of immunodominance following mice immunization with three different hcv epitopic-pep...