introduction: heart secretes hormones such as natriuretic peptide. the purpose of this study was to investigate the effects of 12 weeks of resistance training on these hormones. methods: twenty four healthy men (mean age ± sd: 24.9 ± 3.2 years) were randomly allocated to experimental and control groups. subjects in the experimental group performed a 12-week resistance training program, 3 sessio...

Volumetric absorptive microsampling (VAMS) and dried urine spot (DUS) strategies were applied for the collection of microsamples anti-doping testing low-stability peptide hormones growth factors prohibited by World Anti-Doping Agency (WADA). Drying, storage transport conditions, as well pretreatment steps, optimised before liquid chromatography - tandem mass spectrometry (LC–MS/MS) analysis. Th...

A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human liver using successive steps of chromatography on DEAE-cellulose, hydroxyapatite and Sephacryl S-200. The purified enzyme hydrolyzed the Pro7-Phe8 bond of bradykinin and the Ser25-Tyr26 bond of atrial natriuretic peptide. No cleavage was produced in other peptide hormones such as vasopressin, oxyto...

The heart is a sophisticated endocrine gland synthesizing the atrial natriuretic peptide (ANP) prohormone which contains four peptide hormones, namely atrial natriuretic peptide, vessel dilator, kaliuretic peptide and long-acting natriuretic peptide, which decrease up to 97% of human pancreatic, breast, colon, prostate, kidney and ovarian carcinomas, as well as small-cell and squamous cell lung...

Given the increasing interest in use of peptide- and protein-based agents therapeutic strategies, it is fundamental to develop delivery systems capable preserving biological activity these molecules upon administration, which can provide tuneable release profiles. Electrohydrodynamic (EHD) techniques, encompassing electrospinning electrospraying, allow generation fibres particles with high surf...