نتایج جستجو برای: pentavalent
تعداد نتایج: 1046 فیلتر نتایج به سال:
Pentavalent antimonial drugs such as meglumine antimoniate (Glucantime [Glu; Sanofi-Aventis, São Paulo, Brazil]) produce severe side effects, including cardiotoxicity and hepatotoxicity, during the treatment of leishmaniasis. We evaluated the role of residual Sb(III) in the hepatotoxicity of meglumine antimoniate, as well as the protective effect of the antioxidant ascorbic acid (AA) during ant...
Visceral leishmaniasis (VL) affects over 500,000 people worldwide each year. The disease occurs in the Mediterranean basin, Central and South America and is caused by Leishmania infantum (syn L. chagasi). VL is an endemic disease in Colombia, particularly along the Caribbean coast and the Magdalena River Valley and 90% of VL cases occur in children under the age of five. The first line of treat...
Leishmaniasis is a neglected public health problem caused by the protozoan species belonging to the genus Leishmania affecting mostly the poor populations of developing countries. The causative organism is transmitted by female sandflies. Cutaneous, mucocutaneous, and visceral clinical manifestations are the most frequent forms of leishmaniasis. Chemotherapy still relies on the use of pentavale...
We synthesised and toxicologically characterised the arsenic metabolite thiodimethylarsinic acid (thio-DMA(V)). Successful synthesis of highly pure thio-DMA(V) was confirmed by state-of-the-art analytical techniques including (1)H-NMR, HPLC-FTMS, and HPLC-ICPMS. Toxicological characterization was carried out in comparison to arsenite and its well-known trivalent and pentavalent methylated metab...
INTRODUCTION Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways. CASE PRESENTATION We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid...
Reaction of UO2I2(THF)3 with 1 molar equivalent of KC5R5 (R = H, Me) in pyridine led to the uranyl(V) compound {[UO2(Py)5][KI2(Py)2]}(infinity), which is an infinite 1D polymer in its crystalline form; the UO2X(THF)n (X = I, OSO2CF3) complexes were obtained by reduction of their U(VI) parents with TlC5H5 or KC5R5 in THF.
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