Eagle (1947a) has shown that p-hydroxybenzyl penicillin (X) was more effective than benzyl penicillin (G) in curing mice infected with Streptococcus pyogenes and Streptococcus pneumoniae. Hewitt and Pittman (1946) have obtained similar results in animals infected with Hemophilus influenzae. It was further shown that penicillin X remains in the blood of human subjects longer than penicillins G o...

Concomitant with the extensive use of antibiotics, the number of multiple antibiotic-resistant strains has been increasing. Since resistance is mainly mediated by R plasmids, we undertook to investigate the characteristics of R plasmid-determined beta-lactamase in 6 Gram-negative rods. The beta-lactamase produced by each organism was classified by its substrate: type P which attacks penicillins...

Some recent advances in the chemistry of penicillin are presented. The group of antibiotics known as the penicillins have a unique position in chemistry. Not only were they the first type of antibiotic to be widely accepted in medical practice, but their chemistry proved to be of unusual interest and complexity. Modem fermentation plants have reduced the cost of the penicillins such that one sh...

Semisynthetic penicillins in concentrations greater than 1.0% (wt/vol) were found to inhibit the limulus lysate assay for endotoxin.

The determination of specific IgE in patients with history of penicillins hypersensitivity is simple, safe and widely available. The positive and negative predictive values of this determination, however, are not yet established. In order to evaluate them, we performed specific IgE determination and diagnostic drug challenges in a group of 22 patients with a clear history of immediate penicilli...

The infections that causes by Pseudomonas aeruginosa is usually responsible for the nosocomial of United States. Occurs in each year approximality 51,000 cases P. , and persons most risk infection are those exposer into equipment hospital has not well desinfection such as ventilation mechanical catheters.Some strains mutate or production β-Lactamase enzymes resistance penicillins.The acts on di...