BACKGROUND A short course of systemic corticosteroids is an important therapy in the treatment of pediatric asthma exacerbations. Although a 5-day course of oral prednisone or prednisolone has become the most commonly used regimen, dexamethasone has also been used for a shorter duration (1-2 days) with potential for improvement in compliance and palatability. We reviewed the literature to deter...

BACKGROUND Asthma is a disease resulting from a complex interaction of multiple genetic and environmental factors. More than 200 asthma candidate genes have been identified in the past decades by using genetic association studies, positional cloning and knockout mouse approaches. AIM This study was to identify differentially expressed genes and provide direction for medicine design related to...

BACKGROUND : The wide variability in prevalence of childhood asthma across Asia Pacific is well documented, but less is known about its trends in mortality and hospitalization. OBJECTIVES : To examine pediatric asthma mortality and hospitalization trends of selected countries across Asia Pacific, and also patterns of asthma drug utilization. MATERIALS AND METHODS : Mortality and population ...

BACKGROUND Child maltreatment is a common problem with known adverse consequences, yet its contributions to the development and course of pediatric asthma are only poorly understood. MAIN This review first describes possible pathways connecting child maltreatment to pediatric asthma, including aspects of the physical home environment, health behaviors and disease management, and psychological...

Background: Asthma is one of the most common chronic diseases all over the world, which impacts socioeconomics of families and health care systems. We aimed to investigate the economic burden of pediatric asthmain Iran and to examine its variability depending on asthma severity. Methods: In a descriptive-analytical study 141 pediatric asthmatic patients, who referred to pediatric referral cent...

Background Prevalence of pediatric overweight/obesity and pediatric asthma has been on the rise, with both conditions currently reaching epidemic proportions. Their concurrent rise alludes to potentially common characteristics of their pathophysiologic mechanisms; furthermore, excess fat mass may facilitate asthma induction via obesity-related inflammatory mediators, oxidant stress and mechanic...

Upper respiratory symptoms .21 Yes (n 1⁄4 156) 36 (20-56) Fractional excretion of nitric oxide is associated with acute pediatric asthma exacerbation severity as measured by % predicted FEV1 and is greater in African American patients in comparison with white pediatric patients during exacerbations. Knowledge of these associations might inform the use of fractional excretion of nitric oxide bef...

human metapneumovirus (hmpv) infection plays an important role in the pediatric respiratory infections. the aim of this study was to determine the relationship between asthma and wheezing with hmpv in hospitalized children. nasal pharyngeal swabs obtained from 120 children aged 1-60 months, hospitalized during a one year period, were tested for the hmpv by rt-pcr. hmpv was detected in 20 (16.6%...

BACKGROUND/OBJECTIVE To integrate new evidence into the Canadian Asthma Management Continuum diagram, encompassing both pediatric and adult asthma. METHODS The Canadian Thoracic Society Asthma Committee members, comprised of experts in pediatric and adult respirology, allergy and immunology, emergency medicine, general pediatrics, family medicine, pharmacoepidemiology and evidence-based medic...