Abstract Central nervous system (CNS) tumors are the second most common pediatric cancer; survivors develop chronic medical conditions and complex care needs. While telemedicine is accelerating, its effectiveness has not been assessed in CNS tumor survivors. We evaluated experiences of those seen through our Pediatric Neuro-Oncology Survivorship Clinic at Dana-Farber/ Boston Children’s Cancer B...

Progress in therapy for pediatric hematological malignancies over the last five decades has resulted in remarkable gains in survival for children afflicted by these diseases. Five year survival exceeds 85% for children with acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL) and has reached 60% for those with acute myeloid leukemia (AML) [1]. This success r...

The outlook for children diagnosed with cancer has significantly improved and continued to change since the late 1960s. Due to advances in therapy and diagnosis, the focus of psychological research and service has progressively changed from death and dying to surviving and cure, as well as possible neurobehavioral late effects, which is addressed in the accompanying papers (Moore; Butler & Mulh...

BACKGROUND Most childhood cancer survivors will develop ionizing radiation treatment-related health conditions that, in many instances, resemble age-associated pathologies. Treatment-induced premature senescence could be an underlying mechanism. FINDINGS Here we wanted to know whether the expression of p16INK4a, a senescence/aging biomarker, is increased in skin biopsies of acute lymphoblasti...

CONTEXT Defined as the loss of ovarian function within 5 yr of diagnosis, acute ovarian failure (AOF) is known to develop in a subset of survivors of pediatric and adolescent cancers. Its precise incidence is unknown, and data concerning its risk factors are limited. OBJECTIVE Our objective was to determine the incidence of and patient/treatment factors associated with AOF in a large cohort o...

Background: Most childhood cancer survivors will develop ionizing radiation treatment-related health conditions that, in many instances, resemble age-associated pathologies. Treatment-induced premature senescence could be an underlying mechanism. Findings: Here we wanted to know whether the expression of p16, a senescence/aging biomarker, is increased in skin biopsies of acute lymphoblastic leu...

PURPOSE/OBJECTIVES To report functional (physical and cognitive) late effects, experiences, and information needs of adult survivors of childhood cancer. DESIGN Descriptive, mixed methods survey. SETTING Two pediatric oncology programs in the Midwest. SAMPLE Convenience sample of 272 young adult survivors. METHODS Voluntary survey completion by young adult survivors regarding late effec...

Objective: Mailed surveys are widely used to collect epidemiologic and health service data. Given that nonresponse can threaten the validity of surveys, modest incentives are often used to increase response rates. A study was undertaken among childhood cancer survivors and their parents to determine if response rate to a mailed survey differed with provision of immediate versus delayed incentiv...