Photodynamic diagnosis (PDD) is a practical tool currently used in surgical operation of aggressive brain tumors, such as glioblastoma. PDD is achieved by a photon-induced physicochemical reaction which is induced by excitation of protoporphyrin IX (PpIX) exposed to light. Fluorescence-guided gross-total resection has recently been developed in PDD, where 5-aminolevulinic acid (ALA) or its este...

Introduction Pervasive developmental disorders (PDD) are characterized by social and communication deficits, repetitive and stereotyped behaviours and onset before 3 years of age [1]. Prevalence of PDD has increased over the past 10 years and now it is ranging from 60 to 70 per 10.000 [2], with a male-to-female ratio of 3-4:1; these data do not include the Rett disorder. The dramatic increment ...

This paper presents three new computational methods for calculating design sensitivities of statistical moments and reliability of high-dimensional complex systems subject to random input. The first method represents a novel integration of the polynomial dimensional decomposition (PDD) of a multivariate stochastic response function and score functions. Applied to the statistical moments, the me...

Photobacterium damselae subsp. damselae (PDD) is a known pathogen of fish, humans and marine mammals. In this study, a Multilocus Sequence Typing (MLST) scheme based on six housekeeping genes (glp, gyrB, metG, pnt, pyrC, and toxR) was developed to better understand the PDD population structure and used to type 73 PDD isolates from cetaceans, mainly striped dolphins (Stenella coeruleoalba) invol...

In an attempt to optimize the chemotherapeutic treatment of mouse tumor Sarcoma 180, liposomes containing c/s-dichlorodiammineplatinum(ll) (FDD), having transition temperatures a few degrees higher than the rectal temperature of mice, were used in combination with local hyperthermia. The uptake of radioactive PDD by tumors heated for 1 hr at 42°was almost four-fold greater when the drug was as...

BACKGROUND AND OBJECTIVE Altered levels of naturally occurring autoantibodies (nAbs) against disease-associated neuronal proteins have been reported for neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's disease (PD). Recent histopathologic studies suggest a contribution of both Lewy body- and AD-related pathology to Parkinson's disease dementia (PDD). Therefore, we explored n...

Objective: There are few previously published studies of feeding problems and/or gastrointestinal dysfunction among children with Asperger syndrome (AS) or Pervasive Developmental Disorder (PDD-NOS), compared to sibling controls. Study Design: On-line parent autism groups 90% from North America. Statistical analysis: Chi square and binomial logistic regression statistical analysis Results: Comp...

BACKGROUND In addition to the core symptoms, children with Pervasive Developmental Disorders (PDD) often exhibit other problem behaviors such as aggression, hyperactivity, and anxiety, which can contribute to overall impairment and, therefore, become the focus of clinical attention. Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates o...

OBJECTIVE To analyze the anteroposterior displacement of the knee by means of stress radiography in individuals with unilateral anterior knee instability and relate to time of instability. METHODS Sixty individuals with intact knees (control group) and 125 patients with unilateral anterior instability (AI group) agreed to participate in the study. Gender, age, weight, height, age at injury, t...

Summary Phenotypic drug discovery (PDD) uses biological systems directly for new screening. While PDD has proved effective in the of drugs with novel mechanisms, broader adoption, key challenges need resolution: progression poorly qualified leads and overloaded pipelines due to lack tools process prioritize hits; advancement undesirable mechanisms that fail at more expensive stages dis...