Speech is a complex behavior that is coordinated by an integrated network of sensory, muscular, respiratory, and cognitive systems. As a result of the complex nature of speech, symptoms of speech impairment can be quite diverse, reflecting dysfunction in one or more of these systems. Research has found that speech problems are common in Parkinson’s disease (PD), and it has been found that 70% o...

more than 10 million people worldwide are living with parkinson’s disease (pd). the ages of people who have parkinson are variable, usually between 50 and 80 years, the average of them is 55 years old. the symptoms of pd are progressive, and within 10 to 20. it happens when dopaminergic neurons were being degenerate. peripheral and central inflammatory and oxidative stress pathways play a compl...

Participatory design (PD) involves users in all phases of design to build systems that fit user needs while simultaneously helping users understand complex systems. We argue that traditional PD techniques can benefit participatory sensing: community-based participatory research (CBPR) projects in which complex technologies, such as sensing networks using mobile phones, are the research instrume...

This paper will be the first to discuss the in vivo and in vitro properties of a Pd(II) complex, K2PdCl4, interacting with metallothioneins (MTs). In vivo experiments revealed that intraperitoneal injections of K2PdCl4 into rabbits led to the simultaneous synthesis of Pd-MT in the kidney and Zn7MT in the liver. The renal Pd-MT complex contains 3.6 +/- 0.3 Pd, 2.1 +/- 0.2 Zn, and 1.0 +/- 0.1 Cu ...

The interaction of B7H1 in tumor cells with programmed death-1 (PD-1) in T cells plays an important role in the suppression of immune responses. However, the effects of the expression of B7H1 and the PD-1/programmed death 1 ligand 1 (PD-L1) complex on tumor cells themselves remain largely unknown. In order to clarify this, we induced apoptosis in ...

3-1. 1a–Pd Complexes 8 3-1-1. Detailed NMR of 1a for peak assignments 8 3-1-2. Detailed NMR of 1a/Pd for peak assignments 10 3-1-3. Detailed NMR of (1a)2/Pd for peak assignments 13 3-1-4. Stacked 1H and 13C NMR of 1a, 1a/Pd, and (1a)2/Pd 17 3-2. 1b–Pd Complex 19 3-2-1. Detailed NMR of 1b for peak assignments 19 3-2-2. Detailed NMR of (1b)2/Pd for peak assignments 23 3-2-3. Stacked 1H and 13C NM...

X-ray crystal structures and properties of the two Pd(II) and Pt(II) complexes [bpeH2][PdCl4] and [Pt(bpe)Cl2], [bpe = l,2-bis(pyridin-2-yl)ethane] are described and corre­ lated with the IR and ‘H N M R/13C NMR spectroscopic data. In the case of the Pt(II) com­ plex, the l,2-bis(pyridin-2-yl)ethane is bound to the metal by the heterocycle nitrogen atoms but no direct bond is found in the case ...

The title compound, [PdCl2(C4H4N2)2], contains two crystallographically unique complexes; the Pd(II) atom lies on an inversion center in both cases. The two pyridazine units bonded to the Pd(II) atom are thus coplanar although dihedral angles within each complex are different. In one complex, the angle between the ring plane and Pd-Cl bond is almost perpendicular [89.4 (1)°], while the other is...