We identified Xenopus pericentriolar material-1 (PCM-1), which had been reported to constitute pericentriolar material, cloned its cDNA, and generated a specific pAb against this molecule. Immunolabeling revealed that PCM-1 was not a pericentriolar material protein, but a specific component of centriolar satellites, morphologically characterized as electron-dense granules, approximately 70-100 ...

Phase change memory (PCM) technology appears as more scalable than DRAM technology. As PCM exhibits access time slightly longer but in the same range as DRAMs, several recent studies have proposed to use PCMs for designing main memory systems. Unfortunately PCM technology suffers from a limited write endurance; typically each memory cell can be only be written a large but still limited number o...

Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Central and South America, is caused by the dimorphic fungus Paracoccidioides brasiliensis and has a high prevalence in Brazil. Glycoproteins of 43 and 70 kDa are the main antigenic compounds of P. brasiliensis and are recognized by Western blotting by 100 and 96% of PCM patient sera, respectively. In the present study,...

Disruption of iron homeostasis within the central nervous system (CNS) can lead to profound abnormalities during both development and aging in mammals. The radiation-induced polycythaemia (Pcm) mutation, a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), disrupts transcriptional and post-transcriptional regulation of this pivotal iron transporter. This regulatory mutation ind...

This paper initially describes the relational counterpart of possibilistic c-means (PCM) algorithm, called relational PCM (or RPCM). RPCM is then improved to better handle arbitrary dissimilarity data. First, a re-scaling of the PCM membership function is proposed in order to obtain zero membership values when the distance to prototype equals the maximum value allowed in bounded dissimilarity m...

The ability of the Parallel Climate Model (PCM) to reproduce the mean and variability of hydrologically relevant climate variables was evaluated by comparing PCM historical climate runs with observations over temporal scales from sub-daily to annual. The domain was the continental U.S, and the model spatial resolution was T42 (about 2.8 degrees latitude by longitude). The climate variables eval...

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...

There is an increasing interest in developing Phase Change Memory (PCM) based main memory systems. In order to retain the latency benefits of DRAM, such systems typically have a small DRAM buffer as a part of the main memory. However, for these systems to be widely adopted, limitations of PCM such as low write endurance and expensive writes need to be addressed. In this paper, we propose PCMawa...

Abstruct-Research and development of coherent optical fiber communications have been accelerated mainly because of the possibility of receiver sensitivity improvement reaching 20 dB, and partly because of the possibility of frequency-division multiplexing (FDM) with very fine frequency separation. In this paper, recent advances in the research on coherent optical fiber communication systems are...

Use of a phase change material (PCM)-based heat sink in transient thermal management of plastic quad flat package (QFP) electronic devices was investigated experimentally and numerically. Results show that increased power inputs enhance the melting rate as well as the thermal performance of the PCM-based heat sinks until the PCM is fully melted. A three-dimensional computational fluid dynamics ...