Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are widespread environmental contaminants found in seafood and dairy products. PCBs and PBDEs are structurally similar chemicals and affect thyroid hormone function and behavior in children and laboratory rodents. Although coexposure frequently exists, the in vivo developmental effects of combined exposure to PCBs and P...

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that have attracted great concern in the past few decades. PCBs were first synthesized in 1864 (WHO, 1993) and widely used in the United States between 1929 until their manufacture was banned in 1977 (Erickson, 1986; Nies and Vogel, 1990). Due to the widespread use of PCBs and improper disposal practices, a significant a...

High-frequency and high-speed printed circuit boards (PCBs) are made of ceramic particles anisotropic fibres, which difficult to machine. In most cases, severe tool wear occurs when drilling high-frequency PCBs. To protect the substrate drills, diamond films typically fabricated on drills using hot filament chemical vapour deposition (HFCVD). This study investigates coating characteristics with...

Although PCBs were banned in 1977, they remain a major public health and environmental concern because of their widespread presence. They have been found throughout the world, even in remote locations in the Arctic where no PCBs have ever been used. Estimates are that as much as 3.4 billion pounds of PCBs were manufactured worldwide and that 30 to 70% of the PCBs manufactured remain in use or i...

PCBs have been demonstrated to cause a variety of adverse health effects. PCBs have been shown to cause cancer in animals. PCBs have also been shown to cause a number of serious non-cancer health effects in animals, including effects on the immune system, reproductive system, nervous system, endocrine system and other health effects. Studies in humans provide supportive evidence for potential c...

Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized. The improved method is more sensitive than the conventional method for 5g blood samples. And, th...

Seven "target" PCB levels were determined and compared in waterbird eggs, in their prey, and in water at Lake Kerkini, northern Greece, to investigate PCB bioaccumulation patterns and to define the best bioindicator of target PCBs for this area. PCBs were analysed from eggs of Phalacrocorax carbo, Podiceps cristatus, Ardea cinerea, Egretta garzetta, and Nycticorax nycticorax and from prey types...

OBJECTIVE Our aim in the present study was to characterize and quantify the levels of polychlorinated biphenyls (PCBs) and specific polychlorobiphenylol (OH-PCB) metabolites in maternal sera from women delivering in eastern Slovakia. DESIGN During 2002-2004, blood samples were collected from women delivering in two Slovak locations: Michalovce district, where PCBs were formerly manufactured, ...

BACKGROUND Polychlorinated biphenyls (PCBs) are a group of environmental persistent organic pollutants, which can be metabolized into a series of metabolites, including hydroxylated metabolites (OH-PCBs) in biota. Nineteen of 209 PCB congeners can form chiral stable isomers. However, atropisomeric determination of the hydroxylated metabolites of these chiral PCBs has never been reported by LC m...

Hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) are inhibitors and substrates for various human sulfotransferases (SULTs). Although the rat is often used in toxicological studies on PCBs, the interactions of OH-PCBs with rat SULTs are less well understood. In the present study, 15 OH-PCBs were investigated as potential substrates or inhibitors of purified recombinant rSULT1A1 an...