The present study is an extension of the cooperative kinematics (CK) approach (Bahar, I.; Erman, B.; Monnerie, L.Macromolecules 1992, 25, 6309), which has been demonstrated to give an efficient and realistic account of the mechanism of local relaxational processes in polyethylene (PE). In the present work, the effects of (i) departure from tetrahedral backbone geometry and (ii) differences in t...

OBJECTIVE To use functional neuroimaging to probe the affective circuitry dysfunctions underlying disturbances in emotion processing and emotional reactivity in pediatric bipolar disorder (PBD). METHOD Equal numbers of controls (HC) and unmedicated patients with euthymia and PBD were matched for age, sex, race, socioeconomic status, and IQ (n = 10 per group; mean age 14.2 years [SD 2.0 years]...

We obtained unanticipated synthetic byproducts from alkylation of the δ(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest-affinity byproduct, bearing a C(6)H(5)(CH(2))(8)- group, a Plk1 PBD cocrystal structure revealed a new binding channel that had previously been occluded. An N-terminal PEGylated ver...

Pyrrolobenzodiazepines (PBDs) are covalent-binding DNA-interactive agents with growing importance as payloads in Antibody Drug Conjugates (ADCs). Until now, PBDs were thought to covalently bond to C2-NH2 groups of guanines in the DNA-minor groove across a three-base-pair recognition sequence. Using HPLC/MS methodology with designed hairpin and duplex oligonucleotides, we have now demonstrated t...

Defensins are small antimicrobial peptides (AMPs) that play an important role in the innate immune system of mammals. Since the effect of mycotoxin contamination of food and feed on the secretion of intestinal AMPs is poorly understood, the aim of this study was to elucidate the individual and combined effects of four common Fusarium toxins, deoxynivalenol (DON), nivalenol (NIV), zearalenone (Z...

Polo-like kinase 1 (Plk1) plays several roles in cell division and it is a recognized cancer drug target. Plk1 levels are elevated in cancer and several types of cancer cells are hypersensitive to Plk1 inhibition. Small molecule inhibitors of the kinase domain (KD) of Plk1 have been developed. Their selectivity is limited, which likely contributes to their toxicity. Polo-like kinases are charac...

OBJECTIVE To generate recombinant Bacillus subtilis (B. subtilis) engineered for expression of porcine β-defensin-2 (pBD-2) and cecropin P1 (CP1) fusion antimicrobial peptide and investigate their anti-bacterial activity in vitro and their growth-promoting and disease resisting activity in vivo. METHODS The pBD-2 and CP1 fused gene was synthesized using the main codons of B. subtilis and inse...

Programming-by-demonstration (PBD) is a new paradigm for programming industrial robots enabled by the development of the DLR/KUKA light-weight robot. Although the PBD approach facilitates and simplifies the generation of robot programs, the technician still needs to have skills and knowledge about the robotic system in order to produce efficient trajectories and to exploit the abilities of the ...

Pentaksiran Bilik Darjah (PBD) merupakan sebuah pentaksiran secara berterusan dalam pembelajaran dan pemudahcaraan (PdPc) bagi mengesan perkembangan, mengenal pasti kekuatan kelemahan serta meningkatkan pencapaian murid pembelajaran. Justeru, kajian ini mengkaji tentang tahap kefahaman, kemahiran sikap guru bahasa Melayu sekolah rendah pelaksanaan PBD. Kajian menggunakan pendekatan kuantitatif ...

Peroxisomal biogenesis disorders (PBD) are caused by mutations in PEX genes, and are typically diagnosed with biochemical testing in plasma followed by confirmatory testing. Here we report the unusual diagnostic path of a child homozygous for PEX1 p.G843D. The patient presented with sensorineural hearing loss, pigmentary retinopathy, and normal intellect. After testing for Usher syndrome was ne...