BACKGROUND The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is not fully understood. Moreover, relatively few studies have investigated the...

Although positron emission tomography (PET) and the aromatic L-amino acid decarboxylase (AADC) tracer 6-[(18)F]fluoro-L-m-tyrosine (FMT) has been used to assess the integrity of the presynaptic dopamine system in the brain, relatively little has been published in terms of brain FMT uptake values especially for normal human subjects. Twelve normal volunteer subjects were scanned using PET and FM...

Methods A healthy minipig, measured 5 times using first pass DCE imaging. We sampled the arterial input function (AIF) and the tissue response function (TRF), from the mid-ventricular tissue region from anterior to inferior in the short axis view of the heart, using incoherent imaging (Steady State Incoherent, SSI, or FLASH), and coherent imaging (Steady State Coherent, SSC, or BALANCED) [1] tw...

BACKGROUND The Langendorff perfused heart is a physiologically relevant and controllable model with potential for assessing the pharmacokinetics of new radiotracers under a range of pathophysiological conditions.. We assess the feasibility of extending the methods validated for in vivo PET data analysis to the characterisation of PET tracer kinetics applied to Langendorff perfused hearts. MET...

BACKGROUND Assessment of dual time point (DTP) positron emission tomography was carried out with the aim of a quantitative determination of Km, the metabolic uptake rate of [18F]fluorodeoxyglucose as a measure of glucose consumption. METHODS Starting from the Patlak equation, it is shown that Km≈mt/ca0+V̄r/τa, where mt is the secant slope of the tissue response function between the dual time p...

OBJECTIVES To assess the suitability of analyzing functional images of brain serotonin (5-HT) synthesis with statistical parametric mapping (SPM), and to investigate further possible sex-related regional differences. DESIGN Prospective study. PARTICIPANTS Six healthy men and 5 healthy women. INTERVENTION Participants' brains were scanned with positron-emission tomography (PET) after intra...

Abstract. Variational steepest descent approximation schemes for the modified Patlak-KellerSegel equation with a logarithmic interaction kernel in any dimension are considered. We prove the convergence of the suitably interpolated in time implicit Euler scheme, defined in terms of the Euclidean Wasserstein distance, associated to this equation for sub-critical masses. As a consequence, we recov...

To evaluate the clinical utility of a new method with dynamic single photon emission computed tomography (SPECT) and scatter and attenuation compensation to estimate both total and regional liver function quantitatively. Five controls, 20 patients with chronic liver disease, and 2 patients with Budd-Chiari syndrome were studied. Dynamic liver SPECT data were acquired during 20 minutes after inj...

Hepatic steatosis is associated with obesity and insulin resistance. Whether hepatic glucose utilisation rate (glucose phosphorylation rate; MRglu) is increased in steatosis and/or obesity is uncertain. Our aim was to determine the separate relationships of steatosis and obesity with MRglu. Sixty patients referred for routine PET/CT had dynamic PET imaging over the abdomen for 30 min post-injec...