A fentanyl patch is widely used for the treatment of cancer pain. Its few adverse effects include constipation and drowsiness. The absorption volume of transdermally applied fentanyl may differ according to its site of application and variability in patch adhesion. Since fentanyl is predominantly metabolized by the drug-metabolizing enzyme cytochrome P450 (CYP) 3A4 in the liver, its concentrati...

A problem inherent in information hiding techniques for digital images is that of alignment during data extraction. This alignment problem can be solved using a search approach where a combination of coarse orientation detection, random search and gradient descent methods are employed. When used in conjunction with the Patch Track algorithm, it is possible to create an information hiding and re...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

the support vector machine (svm) is a relatively new machine learning method which is increasingly being applied to engineering problems and have yielded encouraging results. because of complex behavior of elastoplastic of web panels of plate girders under patch loading, almost none of the proposed methods provides consistent and accurate predictions of patch load capacity. consequently, altern...

In this paper, we propose a method to improve image classification performance using the fusion of CNN and transformer structure. case CNN, information about local area on an can be extracted well, but global extraction is limited. On other hand, has advantage in extraction, it requires much memory compared CNN. We apply consider feature vector each pixel resulting map by as token. At same time...

background: cutaneous manifestations are commonly observed in the neonatal period. it is important to differentiate physiologic skin lesions from pathologic ones to avoid parents’ concerns. regarding this, the current study aimed to investigate the frequency and localization of salmon patch (sp) and mongolian spot (ms) in iranian newborns to assess the potential relationship between the neonata...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...