background and objective: intracerebroventricular (icv) injection of streptozotocin (stz) causes cognitive impairment in rats. the beneficial effect of saffron main component, safranal was investigated on icv stz-induced learning, memory, and cognitive impairment in male rats. materials and methods: for this purpose, rats were injected with icv stz bilaterally, on days 1 and 3 (3 mg/kg). the st...

Background: Exposure to electromagnetic radiation may impair memory. This study was conducted to evaluate the effect of radiofrequency wave (hereafter referred to as RFW) on passive avoidance learning and memory in healthy males and females. Materials and Methods: Ten adult male and ten female Sprague-Dawley rats (230±20 gr) were randomly divided into four groups including two control groups (o...

Intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats is followed by long-term and progressive deficits in learning, memory, and cognitive performance which is somewhat similar to sporadic Alzheimer’s disease (SAD). Epidemiological studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) could delay or slow the clinical expression of SAD. Therefore, the benefi...

Introduction: The current study aimed at investigating the existence of the cross state-dependent learning between morphine and scopolamine (SCO) in mice by passive avoidance method, pointing to the role of CA1 area.  Methods: The effects of pre-training SCO (0.75, 1.5, and 3 μg, Intra-CA1), or morphine (1, 3, and 6 mg/kg, intraperitoneal (i.p.) was evaluated on the retrieval of passiv...

Background and Objective: Chlorogenic acid (CGA) is a major polyphenolic component of coffee. Reduction in the risk of a variety of diseases following CGA consumption has been mentioned in recent studies. The effect of CGA on learning and memory in rats with cognitive deficit induced by intracerebroventricular streptozotocin (STZ) and  acetylchoinesterase (AChE) activity was evaluated in this s...

This paper presents a rigorous statistical analysis characterizing regimes in which active learning significantly outperforms classical passive learning. Active learning algorithms are able to make queries or select sample locations in an online fashion, depending on the results of the previous queries. In some regimes, this extra flexibility leads to significantly faster rates of error decay t...

Background and Objective: Temporal lobe epilepsy (TLE) usually leads to memory deficit. In this study, we tried to assess the effect of Withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of TLE in the rat. Materials & Methods: Male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. For induction of epilepsy, unilate...